Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-11-17
1981-06-16
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 12, 23230B, G01N 3348, A61K 4300
Patent
active
042737575
ABSTRACT:
A process and test kit for the quantitative determination of the individual and total unsaturated Vitamin B-12 binding capacities of the three transcobalamins TC-I, TC-II, and TC-III in serum. The process comprises incubating a serum sample with a solution of .sup.57 Co Vitamin B-12, contacting the resulting mixture with a TC-II adsorbent and with a DEAE-cellulose adsorbent for TC-I and TC-III, measuring the total radioactivity adsorbed to said adsorbents, selectively desorbing TC-III from the DEAE-cellulose adsorbent by washing with a monopotassium phosphate solution of about 0.05 M and at a pH of about 4.6, measuring the individual radioactivity adsorbed to each of said adsorbents, and calculating the radioactivity that had been washed from the DEAE-cellulose adsorbent by said phosphate solution. The resulting four radioactivity values are functions of the total, TC-II, TC-I, and TC-III unsaturated Vitamin B-12 binding capacities, respectively, of the serum tested. The test kit comprises the essential elements for performing the present process.
REFERENCES:
patent: 3937799 (1976-02-01), Lewin et al.
patent: 4146602 (1979-03-01), Gutcho et al.
patent: 4167556 (1979-09-01), Selaub et al.
Grossowicz Nathan
Rachmilewitz Bracha
Selhub Jacob
Klawitter Andrew L.
Nucker Christine M.
Padgett Benjamin R.
Yissum Research Development Company
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