Determination of the ultrastructure of connective tissue by...

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

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C600S475000, C436S063000, C436S164000, C436S171000, C250S341200

Reexamination Certificate

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06934576

ABSTRACT:
A method for the evaluation of the ultrastructure of connective tissue, such as cartilage, including (a) providing a probe operative in the near-infrared or mid-infrared region of the electromagnetic spectrum, (b) positioning the probe either to be in contact with the connective tissue (for detecting attenuated total reflectance) or within a sufficient distance from the surface of the connective tissue (for detecting reflection), (c) detecting infrared radiation which penetrates the surface of the connective tissue for detecting attenuated total reflectance or which reflects off the surface of the connective tissue and (d) analyzing the infrared radiation from step (c) for at least one of peak height, peak area and frequency, and comparing at least one of the peak height, the peak area and the frequency for established values for at least one of peak height, peak area and frequency for normal connective tissue to detect a modification in the molecular structure of the connective tissue.

REFERENCES:
patent: 3769963 (1973-11-01), Goldman et al.
patent: 4336809 (1982-06-01), Clark
patent: 4588885 (1986-05-01), Lovoi et al.
patent: 4733660 (1988-03-01), Itzkan
patent: 4737628 (1988-04-01), Lovoi
patent: 4973848 (1990-11-01), Kolobanov et al.
patent: 5038039 (1991-08-01), Wong et al.
patent: 5170056 (1992-12-01), Berard et al.
patent: 5197470 (1993-03-01), Helfer et al.
patent: 5204517 (1993-04-01), Cates et al.
patent: 5280788 (1994-01-01), Janes et al.
patent: 5281798 (1994-01-01), Hamm et al.
patent: 5286947 (1994-02-01), Clyde et al.
patent: 5304173 (1994-04-01), Kittrell et al.
patent: 5346488 (1994-09-01), Prince et al.
patent: 5452716 (1995-09-01), Clift
patent: 5460182 (1995-10-01), Goodman et al.
patent: 5516043 (1996-05-01), Manna et al.
patent: 5527273 (1996-06-01), Manna et al.
patent: 5701913 (1997-12-01), McPherson et al.
patent: 5733739 (1998-03-01), Zakim et al.
patent: 5746736 (1998-05-01), Tankovich
patent: 5762609 (1998-06-01), Benaron et al.
patent: 5769791 (1998-06-01), Benaron et al.
patent: 5772597 (1998-06-01), Goldberger et al.
patent: 5785658 (1998-07-01), Benaron et al.
patent: 5807261 (1998-09-01), Benaron et al.
patent: RE36044 (1999-01-01), Benaron
patent: 5876397 (1999-03-01), Edelman et al.
patent: 5923808 (1999-07-01), Melling
patent: 5986770 (1999-11-01), Hein et al.
patent: 5987346 (1999-11-01), Benaron et al.
patent: 6036667 (2000-03-01), Manna et al.
patent: 6063050 (2000-05-01), Manna et al.
patent: 6068604 (2000-05-01), Krause et al.
patent: 6135774 (2000-10-01), Hack et al.
patent: 6200307 (2001-03-01), Kasinkas et al.
patent: 6270471 (2001-08-01), Hechl et al.
patent: 6324419 (2001-11-01), Guzelsu et al.
patent: 2001/0048077 (2001-12-01), Afanassieva
patent: 2002/0169379 (2002-11-01), Camacho et al.
patent: 19841217 (1999-04-01), None
US 6,230,044, 5/2001, Afanassieva et al. (withdrawn)
Infrared and Raman Spectroscopy of Biological Materials, Eds. Gremlich, H.U., Yan, B., New York, Marcel-Dekker, pp. 323-377 (2001).
Camacho, N.P., Hou, L., Toledano, T.R., Ilg, W.A., Brayton, C.F., Raggio, C.L., Root, L., and Boskey, A.L., “The Material Basis for Reduced Mechanical Properties in Oim Mice Bones”,J. Bone Miner. Res., 14, pp. 264-272, (1999).
Lazarev, Y.A., Grishkovsky, B.A., and Khromova, T.B., “Amide I Band of IR Spectrum and Structure of Collagen and Related Polypeptides”,Biopolymers, 24, pp. 1449-1478, (1985).
Liu, K.Z., Dembinski, T.C., and Mantsch, H.H., “Rapid Determination of Fetal Lung Maturity from Infrared Spectra of Amniotic Fluid”,Am. J. Obstet. Gynecol., 178, pp. 234-241, (1998).
Mendelsohn, R., and Moore, D.J., “Vibrational Spectroscopic Studies of Lipid Domains in Biomembranes and Model Systems”,Chem. Phys. Lipids, 96, pp. 141-157, (1998).
Moore, D.J., Rerek, M.E., and Mendelsohn, R., “Lipid Domains and Orthorhombic Phases in Model Stratum Corneum: Evidence from Fourier Transform Infrared Spectroscopy Studies”,Biochem. Biophys. Res. Commun., 231, pp. 797-801, (1997).
Moore, D.J., Gioioso, S., Sills, R.H., and Mendelsohn, R., “Some Relationships Between Membrane Phospholipid Domains, Conformational Order, and Cell Shape in Intact Human Erythrocytes”,Biochim. Biophys. Acta., 1415, pp. 342-348, (1999).
Paschalis, E.P., Betts, F., DiCarlo, E., Mendelsohn, R., and Boskey, A.L., “FTIR Microspectroscopic Analysis of Normal Human Cortical and Trabecular Bone”,Calcif. Tissue Int., 61, pp. 480-486, (1997).
Paschalis, E.P., Betts, F., DiCarlo, E., Mendelsohn, R., and Boskey, A.L., “FTIR Microspectroscopic Analysis of Human Iliac Crest Biopsies from Untreated Osteoporotic Bone”,Calcif. Tissue Int., 61, pp. 487-492, (1997).
Camacho, N.P., Landis, W.J., and Boskey, A.L., “Mineral Changes in a Mouse Model of Osteogenesis Imperfecta Detected by Fourier Transform Infrared Microscopy”,Connect. Tissue Res., 35, pp. 259-265, (1996).
Camacho, N.P., Rimnac, C.M., Meyer, R.A.J., Doty, S., and Boskey, A.L., “Effect of Abnormal Mineralization on the Mechanical Behavior of X-Linked Hypophosphatemic Mice Femora”,Bone, 17, pp. 271-278, (1995).
Gadaleta, S.J., Camacho, N.P., Mendelsohn, R., and Boskey, A.L., “Fourier Transform Infrared Microscopy of Calcified Turkey Leg Tendon”,Calcif. Tissue Int., 58, pp. 17-23, (1996).
Boskey, A.L., Guidon, P., Doty, S.B., Stiner, D., Leboy, P., and Binderman, I., “The Mechanism of Beta-Glycerophosphate Action in Mineralizing Chick Limb-Bud Mesenchymal Cell Cultures”,J. Bone Miner. Res., 11, pp. 1694-1702, (1996).
Kidder, L.H., Kalasinsky, V.F., Luke, J.L., Levin, I.W., and Lewis, E.N., “Visualization of Silicone Gel in Human Breast Tissue Using New Infrared Imaging Spectroscopy”,Nat. Med., 3, pp. 235-237, (1997).
Lewis, E.N., Kidder, L.H., Levin, I.W., Kalasinsky, V.F., Hanig, J.P., and Lester, D.S., “Applications of Fourier Transform Infrared Imaging Microscopy in Neurotoxicity”,Ann. N.Y. Acad., Sci., 820, pp. 234-247, (1997).
Marcott, C., Reeder, R.C., Paschalis, E.P., Tatakis, D.N., Boskey, A.L., and Mendelsohn, R., “Infrared Microspectroscopic Imaging of Biomineralized Tissues Using a Mercury-Cadmium-Telluride Focal-Plane Array Detector”,Cell. Mol. Biol.(Noisy-le-grand); 44, pp. 109-115, (1998).
Camacho, N.P., Mendelsohn, R., Grigiene, R., Torzilli., P.A., “Polarized FI-IR Microscopic Determination of Collagen Orientation in Articular Cartilage”, 42nd Annual Meeting, Orthopaedic Research Society, Feb. 19-22, 1996, Atlanta, Georgia.
Camacho, N.P., West, P., Torzilli, P.A., Mendelsohn, R., “FTIR Microscopic Imaging of Collagen and Proteoglycan in Bovine Cartilage”,Biopolymers, 62:1-8 (2001).
Potter, K., Kidder, L.H., Levin, I.W., Lewis E.N., Spencer R.G., “Imaging of Collagen and Proteoglycan in Cartilage Sections Using Fourier Transform Infrared Spectral Imaging”,Arthritis&Rheum44(4) :846-855 (2001).
Schumacher, H.R., Klippel, J.H., and Koopman, W.J., “Articular Cartilage”,Primer on the Rheumatic Diseases, 11thedition, Atlanta: The Arthritis Foundation, pp. 14-18, (1993).
Horecker, B., Kaplan, N.O., Marmur, J., and Scheraga, H.A., “Collagens”,Conformation in Fibrous Proteins and Related Synthetic Polypeptides, New York: Academic Press, editors Fraser, R.D.B. and MacRae, T.P., pp. 344-402, (1973).
George, A., and Veis, A., “FTIRS in H2O Demonstrates that Collagen Monomers Undergo a Conformational Transition Prior to Thermal Self-Assembly In Vitro”,Biochemistry, 30, pp. 2372-2377, (1991).
Lazarev, Y.A., Grishkovsky, B.A., Khromova, T.B., Lazareva, A.V., and Grechishko, V.S., “Bound Water in Collagen-Like Triple Helical Structure”,Biopolymers, 32, pp. 189-195, (1992).
Bychkov, S.M., and Kuzmina, S.A., “Study of Tissue Proteoglycans by Means of Infrared Spectroscopy”,Biull. Eksp. Biol. Med., 114, pp. 246-249, (1992).
Bychkov, S.M., Bogatov, V.N., and Kuzmina, S.A., “Infrared Spectra of Cartilag

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