Determination of the thyroxine-binding index in serum

Details Determination of the thyroxine-binding index in serum Determination of the thyroxine-binding index in serum

1981-05-15

1984-08-21

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435810, 436500, 436527, 436810, G01N 3354, G01N 3358, G01N 3378

Patent

active

044670303

ABSTRACT:
A method for the determination of the thyroxine-binding index in serum, which method comprises mixing the serum sample to be determined with a defined amount of thyroxine and a defined amount of a determinable enzyme covalently bound to thyroxine, contacting the resulting solution with anti-thyroxine antibodies present in the solid phase, separating the liquid phase from the solid phase, and measuring the activity of said determinable enzyme in one of the phases as a measure of the tyroxine-binding index in said serum sample.

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patent: 4168207 (1979-09-01), Yoshida et al.
Schall, et al., "A Sensitive Manual Enzyme Immuno Assay for Thyroxine", Clin. Chem., vol. 24, No. 10, (1978), pp. 1801-1804.
Kleinhammer, et al., "Enzyme Immuno Assay for Determination of Serum Thyroxine in Antibody Coated Tubes", Clin. Chem., vol. 23, No. 6, (1977), p. 1123.
Kleinhammer et al., "Enzyme Immuno logical Determination of T.sub.4 and T.sub.3 in Antibody-Coated Glass Tubes", Chem. Absts., vol. 89, No. 7, p. 260, (1978), Abs. No. 55950c.

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