Determination of suppressor functional reserve

Details Determination of suppressor functional reserve Determination of suppressor functional reserve

1986-02-24

1989-10-24

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4352402, 435948, C12Q 102, C12N 500

Patent

active

048761931

ABSTRACT:
Methods are described for assaying, in vitro, the capacity of a subject's lymphocytes to manifest suppressor function. PBLs are exposed to an agent stimulating suppressor cell formation and/or activation. Other PBLs are treated to induce a cell proliferative response, thereby producing responder cells. The responder cells are subjected to an antigen in the presence of the suppressor cells previously produced and in the presence of various concentrations of an amplifier. The procedure provides a means of ascertaining suppressor capacity of the subject's immune system, i.e., the subject's potential to express suppressor function, thereby permitting assay of severity of autoimmune disease, titrating dosage of immunomodulatory agents, and determining whether modulator therapy is feasible.

REFERENCES:
patent: 4728614 (1988-03-01), Lau
patent: 4778750 (1988-10-01), Gottlieb

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