Determination of serine proteases

Details Determination of serine proteases Determination of serine proteases

1979-10-22

1981-06-30

Naff, David M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

2601125R, 435 23, C12Q 156, C12Q 138

Patent

active

042763754

ABSTRACT:
Serine proteases in a substance such as blood are determined by contacting the substance with a novel chromogenic or fluorgenic substrate for serine proteinases and spectrophotometrically measuring the quantity of a chromophore or fluorescent compound released from the substrate by serine proteases in the substance. The novel substrate has the amino acid sequence-ILe-A-Gly-Arg-wherein A is Asp or Glu substituted in the carboxylic group by esterification or amidation. The novel substrate increases sensitivity and accuracy of the determination.

REFERENCES:
patent: 4016042 (1977-04-01), Svendsen
patent: 4028318 (1977-06-01), Anrell et al.
patent: 4061625 (1977-12-01), Akenstam et al.
patent: 4070245 (1978-01-01), Svendsen
patent: 4137225 (1979-01-01), Ekenstam et al.

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