Determination of protecting anti-HBV immunoglobulins

Details Determination of protecting anti-HBV immunoglobulins Determination of protecting anti-HBV immunoglobulins

1984-08-27

1987-10-20

Warden, Robert J.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 7, 435 28, 436531, 436544, 436545, 436546, 436800, 436809, 436819, 436820, 424 89, G01N 33543, G01N 33569, A61K 3929

Patent

active

047014210

ABSTRACT:
A novel method for the determination of protecting anti-HBV immunoglobulins is based on the use of two different HBsAg reagents: one insolubilized and having the antigenic type AX and one labelled and having the antigenic type AY, wherein A represents the epitope or epitopes which are common to all HBsAg serotyes, wherein X and Y both represent combinations of the epitopes which are not common to all HBsAg serotypes, and where the combinations X and Y have no epitopes in common.

REFERENCES:
patent: 4197361 (1980-04-01), Hoff
Hoofnagle, Gastroenterology 72, p. 290-296, 1977.
Shenertz, New England J. Med. 309, p. 1519, 1983.
Swenson, J. Clinical Microbiology 18(2), p. 305-309, 1983.
L. Matthyssen et al., A Sandwich Enzyme-Immunoassay for Antibodies Against the "A"-Deferminant of HBsAg Using Monoclonal Subtype-Specific Enzyme Labelled Antibodies, Abstract, Symposium of the European Society Against Virus Research, Clermont-Ferrand, France, Sep. 12 to 15, 1983.

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