Determination of pH including hemoglobin correction

Details Determination of pH including hemoglobin correction Determination of pH including hemoglobin correction

2005-09-13

2005-09-13

Winakur, Eric F. (Department: 3736)

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

C600S310000, C600S473000

Reexamination Certificate

active

06944487

ABSTRACT:
Methods and apparatuses of determining the pH of a sample. A method can comprise determining an infrared spectrum of the sample, and determining the hemoglobin concentration of the sample. The hemoglobin concentration and the infrared spectrum can then be used to determine the pH of the sample. In some embodiments, the hemoglobin concentration can be used to select an model relating infrared spectra to pH that is applicable at the determined hemoglobin concentration. In other embodiments, a model relating hemoglobin concentration and infrared spectra to pH can be used. An apparatus according to the present invention can comprise an illumination system, adapted to supply radiation to a sample; a collection system, adapted to collect radiation expressed from the sample responsive to the incident radiation; and an analysis system, adapted to relate information about the incident radiation, the expressed radiation, and the hemoglobin concentration of the sample to pH.

REFERENCES:
patent: 5355880 (1994-10-01), Thomas et al.
patent: 5792050 (1998-08-01), Alam et al.
patent: 5885212 (1999-03-01), Scharlack
patent: 6178346 (2001-01-01), Amundson et al.
patent: 2003/0109772 (2003-06-01), Mills
J. Todd Kuenstner and Karl H. Norris,Spectrophotometry of Human Hemoglobin in the Near Infrared Region from 1000 to 2500 nm; J. Near Infrared Spectroscopy 2, 59-65 (1994).
David M. Haaland and Edward V. Thomas,Partial Least-Squares Methods for Spectral Analyses 1. Relation to Other Quantitative Calibration Methods and the Extraction of Qualitative Information; Anal. Chem., 60, pp. 1193-1202 (1988).
M. Kathleen Alam, Mark R. Rohrscheib, James E. Franke, Thomas M. Niemczyk, John D. Maynard, and M. Ries Robinson,Measurement of pH in Whole Blood by Near-Infrared Spectroscopy; Applied Spectroscopy vol. 53, No. 3, pp. 316-324 (1999).
M. Kathleen Alam, James E. Franke, Thomas M. Niemczyk, John D. Maynard, Mark R. Rohrscheib, M. Ries Robinson, R. Philip Eaton,Characterization of pH Variation in Lysed Blood by Near-Infrared Spectroscopy; Applied Spectroscopy, vol. 52, No. 3, pp. 393-399 (1998).
Songbiao Zhang, Babs R. Soller, Ronald H. Micheels,Partial Least-Squares Modeling of Near-Infrared Reflectance Data for Noninvasive in Vivo Determination of Deep-Tissue pH; Applied Spectroscopy, vol. 52, No. 3, pp. 400-406 (1998).
Songbiao Zhang, Babs R. Soller, Shubjeet Kaur, Kristen Perras, Thomas J. Vander Salm,Investigation of Noninvasive in Vivo Blood Hematocrit Measurement Using NIR Reflectance Spectroscopy and Partial Least-Squares Regression; Applied Spectroscopy, vol. 54, No. 2, pp. 294-299 (2000).
M. Kathleen Alam, James E. Franke, Mark R. Rohrscheib, David Nunez, Vincent Abate, John D. Maynard, Gabor J. Kemeny,Hemoglobin Correction for Near Infrared pH Determination in Lysed Blood Solutions; Applied Spectroscopy, vol. 57, 1093-1099 (2003).

Affiliated with

Also associated with

Rating

Determination of pH including hemoglobin correction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Determination of pH including hemoglobin correction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Determination of pH including hemoglobin correction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3402576