Determination of oxidized .alpha.-1-proteinase inhibitor in seru

Details Determination of oxidized .alpha.-1-proteinase inhibitor in seru Determination of oxidized .alpha.-1-proteinase inhibitor in seru

1984-09-27

1986-08-12

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435184, C12Q 138, C12N 999

Patent

active

046056165

ABSTRACT:
A new method of determining oxidized .alpha.-1-proteinase inhibitor in serum or plasma for use in studying the development of chronic obstructive lung disease is disclosed. Levels of oxidized .alpha.-1-proteinase inhibitor indicate the potential for emphysema development with higher levels showing a decrease in lung protection against elastolytic enzymes such as elastase. This method can be used for patients with a potential for chronic obstructive lung disease rather than having to use bronchial lavage methods for such patients. No other method is known to exist for determining oxidized .alpha.-1-proteinase inhibitor in serum or plasma.

REFERENCES:
Beatty et al., Chemical Abstracts, 97: 121454n, 168-169 (1982).
Abrams et al., Proc. Nat'l. Acad. Sci. USA, 78(12): 7483-7486 (1981).
Carp et al., Proc. Nat'l. Acad. Sci. USA, 79: 2041-2045 (Mar. 1982).
Turins et al., Science, 165: 709-710 (1969).
Travis et al., Methods in Enzymology, 80, Academic Press, New York, 754-765 (1981).

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