Chemistry: analytical and immunological testing – Automated chemical analysis – With a continuously flowing sample or carrier stream
Patent
1992-08-28
1994-02-08
Housel, James C.
Chemistry: analytical and immunological testing
Automated chemical analysis
With a continuously flowing sample or carrier stream
436 45, 436 71, 422 81, 422 72, G01N 3508
Patent
active
052847730
ABSTRACT:
A continuous flow analysis system measures the cholesterol distribution among different lipoprotein classes in a blood sample. A blood plasma sample is separated into different lipoprotein classes by single vertical spin density gradient ultracentrifugation. The sample is then introduced in a continuous succession into a continuous reagent stream which flows through a detector. A signal of the reaction, such as the absorbance of the reaction product, is continuously monitored as the reaction mixture flows through the detector. The detector measures a transient signal thus allowing a relatively short reaction period. The absorbance data is digitized and analyzed with the help of a computer to generate a cholesterol profile indicative of the cholesterol concentration in each lipoprotein class.
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Kulkarni Krishnaji R.
Segrest Jere P.
Housel James C.
The UAB Research Foundation
Wallenhorst Maureen M.
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