Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-10-30
1993-04-27
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 75, 435 792, 436501, 436518, 436531, 436548, G01N 33543, G01N 33577
Patent
active
052061442
ABSTRACT:
The concentration of glycated hemoglobin, HbA.sub.1c, in hemoglobin from diabetic patients is regarded as a useful means of assessing the adequacy of diabetes control. This invention comprises a monoclonal antibody which, due to its specific binding of HbA.sub.1c, can be used for the determination of HbA.sub.1c in the absence of prior denaturation, in blood samples by such analytical methods as radioimmuno assay or enzyme-linked immunosorbent assay. The invention also comprises hybridoma cell lines which produce monoclonal antibodies of the invention.
REFERENCES:
patent: 4187075 (1980-02-01), Noller
patent: 4228237 (1980-10-01), Hevely et al.
patent: 4247533 (1981-01-01), Cerami et al.
patent: 4478744 (1984-10-01), Mezei et al.
patent: 4497900 (1985-02-01), Abram et al.
patent: 4629692 (1986-12-01), Dean
patent: 4658022 (1987-04-01), Knowles et al.
patent: 4727036 (1988-02-01), Knowles et al.
patent: 4778752 (1988-10-01), Curtiss et al.
patent: 4797473 (1989-01-01), Tarsio et al.
patent: 4806468 (1989-02-01), Wagner et al.
patent: 4876188 (1989-10-01), Smith et al.
Biotechnology (catalogue of Fisher Scientific Co. 1983) p. 97.
Cooper Biomedical Research Products Catalogue, Mar. 1, 1985, pp. 15-16.
M. Roth, Clin. Chem., 29, 1991 (1983).
J. S. Schwartz et al., Annals of Intern. Med., 101, 710-713 (1984).
R. E. Dickerson and I. Geis, Hemoglobin: Structure, Function, Evolution, and Pathology, pp. 40-41, The Benjamin/Cummings Publ. Co. (1983).
Clinical Chemistry, vol. 27, No. 11, Nov. 1981, pp. 1797-1806, Easton, Penna., US; E. D. Sevier et al.: "Monoclonal antibodies in clinical immunology" *Whole article*.
Kruse Viggo
Prento Annette
Zeuthen Jesper
Novo Industri A/S
Saunders David
LandOfFree
Determination of glycated (glycosylated) hemoglobin in blood does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Determination of glycated (glycosylated) hemoglobin in blood, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Determination of glycated (glycosylated) hemoglobin in blood will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2326557