Determination of concentrations of biological substances using r

Details Determination of concentrations of biological substances using r Determination of concentrations of biological substances using r

1993-11-30

1996-09-10

Smith, Ruth S.

Surgery

Truss

Pad

128634, 395 25, 395924, 25033907, 2503411, A61B 500

Patent

active

055536166

ABSTRACT:
The concentration of a substance, such as glucose, in a biological sample, such as human tissue (e.g. the skin of an index finger) is non-invasively determined by directing the output beam of a laser diode onto and into the skin so as to cause Raman scattering. The output of a charge coupled device, upon which the scattered light is spatially dispersed according to frequency is digitized and applied to a processor. The processor compares the Raman scattering intensity characteristics of the sample with a comparative model, in particular, an artificial neural network discriminator (ANND). The ANND is trained with a plurality of Raman spectral characteristics from biological fluids or tissue, possessing known Raman scattered light intensities versus wavelength characteristics at known concentrations. A preferred implementation of the ANND employs fuzzy adaptive resonance theory-mapping (ARTMAP), which has robust noise rejection capabilities and can readily handle nonlinear phenomena.

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"An Idea Whose Time Has Come?" by Shauna S. Roberts; Diabetes Forecast, May, 1993; pp. 25-27.

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