Determination of antibiotic concentration in bone

Details Determination of antibiotic concentration in bone Determination of antibiotic concentration in bone

2007-05-02

2008-09-23

Warden, Jill (Department: 1797)

Chemistry: analytical and immunological testing

Inorganic acid or base

Reexamination Certificate

active

07427507

ABSTRACT:
A method of determining the concentration of antibiotic in bone comprising crushing the bone, adding a stabilizing agent to the bone, homogenizing the bone in an extraction solvent to obtain a homogenous suspension, and analyzing the suspension supernatant to determine the concentration of antibiotic in bone.

REFERENCES:
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patent: WO00/76556 (2000-12-01), None
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Hansen, I.; Lykkegaard Nielsen, M.; Nielsen, J.B. “A New Method for Homogenization of Bone Exemplified by Measurement of Trimethoprim in Human Bone Tissue.” Acta pharmacol. et toxicol. 1975, 37, 33-42.
Malincarne L; Ghebregzabher, M.; Moretti, M.V.; Egidi, A.M.; Canovari, B.; Tavolieri, G.; Francisci, D.; Cerulli, G.; Baldelli, F. “Penetration of moxifloxacin into bone in patients undergoing total knee arthroplasty.” Journal of Antimicrobial Chemotherapy. 2006 57, 950-954.
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Polec, R. B.; Yeh, S.D.; Shils, M.E. “Protective Effect of Ascorbic Acid, Isoascorbic Acid, and Mannitol Against Tetracycline-induced Nephrotoxicity.” The Journal of Pharmacology and Experimental Therapeutics, 1971, 178(1), pp. 152-158.
Web Archive Publication of Wyeth's Tygacil. Archival Date: Dec. 31, 2005.

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