Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving cholesterol
Patent
1990-04-27
1995-04-04
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving cholesterol
422 58, 422 61, 422 72, 435 74, 435 17, 435 22, 435 26, 435962, 436 71, 436518, 436528, 436531, 436536, 436538, 436539, 436541, 436807, 436824, 436825, C12Q 160, G01N 33543
Patent
active
054037450
ABSTRACT:
A method is provided, in one embodiment, for the determination of an analyte in a biological fluid sample in the presence of a substance interfering with an assay for the analyte. This embodiment is implemented by using antibodies to cause the selective immunoreaction of at least one of the analyte or the interfering substance and then conducting an assay for the analyte in at least one of the immunoreactants or the non-reactants. Another embodiment provides a disposable reaction device to implement the method. The invention is applicable to the detection of a wide variety of analytes, including cholesterol in a targeted lipoprotein class in the presence of cholesterol in another class; to targeted isozymes of enzymes such as creatine kinase, lactate dehydrogenase, amylase, and alkaline or acid phosphatases in the presence of other isozymes; as well as to targeted immunoglobulins in the presence of non-targeted immunoglobulins.
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Byrnes Ronald J.
Ollington James F.
Pogorzelski Donald E.
Chin Christopher L.
Genzyme Corporation
Scheiner Toni R.
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