Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-07-25
1998-06-30
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 4, 435 912, 435 9152, 536 235, 536 2431, 536 2433, 530350, 935 9, 935 78, C07H 2104, C12Q 168, C12P 1934, G01N 3353
Patent
active
057732205
ABSTRACT:
The invention is directed to a method for screening for the risk of developing Alzheimer's disease (AD) in a subject by detecting the presence or absence of the APOE4 allele and the presence or absence of the ACT alleles which modify the risk of AD associated with the APOE4 allele. The invention offers a non-invasive method to identify individuals at high risk for the development of AD.
REFERENCES:
patent: 5508167 (1996-04-01), Roses et al.
Faber et al. Journal of Hepatology 1993. 18:313-321.
Kamboh, Hum. Biol. 67:195-215, 1995.
Abraham et al., Cell 52:487-501, 1988.
Picken et al., J. Neuropathol. Exp. Neurol. 49:41-48, 1990.
Rozemuller et al., Acta Neuropathol. 82:200-207, 1991.
Shoji et al., Am. J. Pathol. 138:247-257, 1991.
Fraser et al., J. Neurochem. 61:298-305, 1993.
Ishiguro et al Virchows Archi. B. Cell Pathol. 64:221-227, 1993.
Wisniewski et al., Exp. Neurol. 110:121-126, 1990.
Matsubara et al., Ann. Neurol. 28:561-570, 1990.
DeKosky et al., Neurology 44:A354-355, 1994.
McKhann et al., Neurology 34:939-944, 1984.
Khachaturian, Arch. Neurol. 42:1097-1105, 1985.
Mirra et al., Neurology 41:479-486, 1991.
Eichner et al., Arteriosclerosis 10:379-385, 1990.
Randall et al., Science 243:1156-1159, 1989.
Matsubara et al., Ann. Neurol. 28:561-567, 1990.
Rayford et al., J. Neurochem. 58:88-94, 1992.
Wisniewski et al., Am. J. Pathol. 145:1030-1035, 1994.
Sanan et al., J. Clin Invest. 94:880-889, 1994.
Strittmatter et al., Exp. Neurol. 125:163-171, 1994.
Sanan et al., J. Clin. Invest. 94:860-869, 1994.
Nicoll et al., Nature Med. 1:135-137, 1995.
Abraham et al., Neurobiol. Aging 11:123-129, 1990.
Strittmatter et al., Proc. Natl. Acad. Sci. 90:1977-1981, 1993.
Kamboh et al., Atherosclerosis 112:145:149, 1995.
Ma et al., Nature 372:92-94, 1994.
Roses, Annals. Neurol. 38:6-14, 1995.
Saunders et al., Neurology 43:1467-1472, 1993.
Kamboh et al., Nature Genetics 10:486-488, 1995.
Kamboh et al., Ann. Neurol. 38:967-969, 1995.
DeKosky Steven T.
Kamboh M. Ilyas
Myers Carla J.
University of Pittsburgh
LandOfFree
Determination of Alzheimer's disease risk using apolipoprotein E does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Determination of Alzheimer's disease risk using apolipoprotein E, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Determination of Alzheimer's disease risk using apolipoprotein E will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1857579