Determination and quantification of red blood cell...

Details Determination and quantification of red blood cell... Determination and quantification of red blood cell...

2004-03-01

2009-02-03

Gabel, Gailene R (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C422S067000, C422S068100, C435S007210, C435S018000, C435S287200, C435S973000, C436S015000, C436S063000, C436S066000, C436S172000, C436S177000

Reexamination Certificate

active

07485433

ABSTRACT:
The invention relates to the detection and determination of erythrocytopathies and hemoglobinopathies. The invention provides a method for distinguishing between subsets of red blood cells in a sample involving contacting the sample with at least a first marker reagent reactive with a first component of a red blood cell and with at least a second marker reagent reactive with a second component of a red blood cell and determining the reactivity of the marker reagents with the cells.

REFERENCES:
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patent: 6534279 (2003-03-01), Agthoven et al.
patent: WO 03/021275 (2003-03-01), None
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Davis, et al., Detection of fetal red cells in fetomaternal hemorrhage using a fetal hemoglobin monoclonal antibody by flow cytometry, Immunohematology, Aug. 1998, pp. 749-756, vol. 38.
Brady et al., Expression of the human carbonic anhydrase I gene is activated late in fetal erythroid development and regulated by stage-specific trans-acting factors, British Journal of Haematology, 1990, pp. 135-142, vol. 76.
Kondo et al., Estimations of Active and Inactive Carbonic Anhydrase Isozyme B in Human Red Cells, Clinica Chimica Acta, May 1975, pp. 347-353, vol. 60, No. 3.
Taniguchi et al., Carbonic Anhydrase Isozymes, Hemoglobin-F and Glutathione Levels in Lead-exposed Workers, Clinica Chimica Acta, 1975, pp. 29-34, vol. 59, No. 1.
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