Determination and identification of active compounds in a compou

Details Determination and identification of active compounds in a compou Determination and identification of active compounds in a compou

1996-07-16

1999-02-02

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435962, 530412, C12Q 168, C07K 122

Patent

active

058663347

ABSTRACT:
Libraries of compounds such as nucleic acids or peptides are contacted with a target molecule and libraries that have at least one compound that bind with at least a minimum activity are determined by a reiterative process in which a change in the rate of recovery (elimination) of compounds that bind to the target indicates that the library contains such a compound. The procedure may also be used to determine indirectly the sequence of such compound by employing sublibraries, each of which have a known entity at a known position of the compound.

REFERENCES:
patent: 5002867 (1991-03-01), Macevicz
patent: 5270163 (1993-12-01), Gold et al.
Needels et al., PNAS, USA 90: 10700-10704 (Nov. 1993).
Houghten et al. Biotechniques 13(3): 412-421 (1992).
Houghten et al. Nature 354: 84-86 (Nov. 7, 1991).
Oliphant, et al., Mol. Cell. Biol., vol. 9, No. 7, pp. 2944-2949 (1989).
Ecker, et al., Nucl. Acids Res., vol. 21, No. 8, pp. 1853-1856 (Mar. 18, 1993).
Devlin, et al., Sciences, vol. 249, pp. 404-406 (Jul. 1990).
Brenner, et al., Proc. Nat. Acad. Sci., vol 89, pp. 5381-5383 (Jun. 1992).
Lam, et al., Nature, vol 354, pp. 82-84 (Nov. 7, 1991).
Houghten, et al., Nature, vol. 354, pp. 84-86 (Nov. 7, 1991).
Houghten, Gene, vol. 137, pp. 7-11 (1991).
Pinilla, et al., Gene, vol. 128, pp. 71-76 (1993).
Bunin, et al., J. Am Chem. Soc., pp. 10997-10998 (1992).
Tuerk & Gold, Science 249: 505-10 (3 Aug. 1990).

Affiliated with

Also associated with

Rating

Determination and identification of active compounds in a compou does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Determination and identification of active compounds in a compou, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Determination and identification of active compounds in a compou will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1116142