Detergent-free hepatitis C protease

Details Detergent-free hepatitis C protease Detergent-free hepatitis C protease

1997-09-24

1999-01-19

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435183, C12N 950, C12N 900

Patent

active

058612971

ABSTRACT:
The protease of Hepatitis C virus (HCV) is purified without detergent, and is useful as a screening tool for HCV antivirals as well as a diagnostic tool for diseases resulting from HCV infection.

REFERENCES:
patent: 5371017 (1994-12-01), Houghton et al.
E. M. Wondrak et al., FEBS Letters, 280(2); pp. 347-350 (1991).
C. Lin et al., Nat Acad. of Sci., 92; pp. 7622-7626 (1995).
E. D. A. D'Souza et al., J. Gen Virology, 76(2); pp. 1729-1736 (1995).
I. Shoji et al., Hepatology, 22(6), pp. 1648-1655 (1995).

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