Detector and localizer for low energy radiation emissions

Details Detector and localizer for low energy radiation emissions Detector and localizer for low energy radiation emissions

1987-03-17

1989-01-31

Howell, Janice A.

Radiant energy

Invisible radiant energy responsive electric signalling

25037001, G01T 1161

Patent

active

048018031

ABSTRACT:
A detector particularly suited for use in immuno-guided surgery capable of detecting very faint gamma emissions and thereby localizing cancerous tumor. The detector employs a hand manipular probe within which is contained a crystal such as cadmium telluride which is secured in a light tight compressively restrained environment employing compliant yet conductive components which also serve to exhibit varying accoustical impedance to impinging microphonic effects. A preamplifier is incorporated within the probe device itself which employs an integrator stage front end combining a field effect transistor and bipolar device with a very small feedback capacitance of less than one picofarad. A bootstrap technique is utilized to enhance the amplification of the bipolar amplification stage. Pulse related signals outputted from the device are normalized and compared to produce pulse data which are analyzed. In one mode of operation a siren effect is employed to guide the surgeon towards emission sources.

REFERENCES:
Richard D. Baxter, "Miniature Hybrid Preamplifier for CdTe Detectors." IEEE Transactions on Nuclear Science, vol. NS-23, No. 1 (Feb. 1976) pp. 493-497.
P. J. O'Dwyer et al., "Intraoperative Probe-Directed Immunodetection Using a Monoclonal Antibody" Archives of Surgery, vol. 121 (Dec. 1986) pp. 1391-1394.
D. T. Martin et al., "Intraoperative Radioimmunodetection of Colorectal Tumor with a Hand-Held Radiation Detector" American Journal of Surgery, vol. 150, No. 6, (Dec. 1985) pp. 672-675.
D. R. Aitken et al., "Portable Gamma Probe for Radioimmune Localization of Experimental Colon Tumor Xenografts" Journal of Biological Research , vol. 36, No. 5 (1984) pp. 480-489.
E. W. Martin, Jr., et al., "Radioimmunoguided Surgery: Intraoperative Use of Monoclonal Antibody 17-1A in Colorectal Cancer" Hybridoma, vol. 5, Supplement 1 (1986) pp. S97-S108.

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