Detection reagent, article, and immunoassay method

Details Detection reagent, article, and immunoassay method Detection reagent, article, and immunoassay method

1994-01-04

1996-10-01

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 792, 435 794, 435 795, 435971, 435973, 435805, 436513, 436518, 436523, 436533, 436828, 422 56, G01N 33543, G01N 33569

Patent

active

055610455

ABSTRACT:
The binding site on an immunoglobulin for a protein is blocked by hydrophobically coupling the immunoglobulin to a blocking agent such as a label. This results in a detection reagent useful in a variety of test assays in which a protein and an immunoglobulin are advantageously used together, but separately. The reagent is useful in the simultaneous determination of IgG and one of IgA or IgM. Anti-IgA-IgG or anti-IgM-IgG is coupled to a hydrophobic label, particularly a pigment or dye, which label blocks the binding site on IgG for Protein A, and labeled Protein A is added.

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