Detection of very large molecular ions in a time-of-flight mass

Details Detection of very large molecular ions in a time-of-flight mass Detection of very large molecular ions in a time-of-flight mass

1994-05-19

1995-10-31

Berman, Jack I.

Radiant energy

Ionic separation or analysis

250283, H01J 4926

Patent

active

054632188

ABSTRACT:
The invention relates to a method and a device for detecting very large molecular ions in a time-of-flight mass spectrometer, in which the molecules to be detected first fall with high energy (>8 keV) onto a conversion dynode and are then converted into an electronic signal in a sequence of stages. The rnolecules to be detected are at least partly converted into small (<200 u) positive and negative secondary ions on the conversion dynode. The secondary ions formed are accelerated, optionally positive or negative, onto a microchannel plate, where they are converted into electrons. The electrons are amplified in the microchannel plate and then accelerated onto a scintillator. The electron signal is converted into a light signal in the scintillator, being further amplified. A connecting fiber-optic light guide supplies the photons to a photomultiplier, in which they are converted in customary manner into a signal which can be evaluated electronically.

REFERENCES:
patent: 4267448 (1981-05-01), Feser et al.
patent: 4322629 (1982-03-01), Eloy et al.
patent: 4988867 (1991-01-01), Laprade
patent: 4988868 (1991-01-01), Gray
patent: 5202561 (1993-04-01), Giessmann et al.
Boesl, et al. Mass Resolution of 10,000 in a Laser Ionization Time-of-Flight Mass Spectrometer, Int. Journal of Mass Spectronomy and Ion Processes, 71 (1986) 309-313, Elsevier Science Publishers B.V. Amsterdam.
Karas et al. Laser Desportion Ionization of Proteins with Molecular Masses, Anal., Chem 1988, 60, pp. 2299-2301.
Tanaka et al., Protein and Polymer Analyses up to m/z 100 000 by Laser Ionization Time-of-Flight Mass Spectr., Rapid Comm. in Mass Spectr., vol. 2, No. 8, 1988.
Electron and Ion Conversion from Large Molecular Ions Incidsent on Various Surfaces, J. Martens, et al. University of Manitoba.
The Analysis of Water-Soluble Polymers by Matrix-Assisted Laser Desorption Time-of-Flight, OMS Letter, Organic Mass Spec vol. 27, 843-846, 1992.
Time-of-Flight Spectrometer for Mass Identification of Heavy Ions, Dietz et al., pp. 581-586, Nuclear Instr. & Methods, 97.
Characteristics of a Multichannel Electrooptical Detection System and its Application to the Analysis of Large Molecules by Fast Atom Bombardment of Mass Spectrometry, Anal. Chem. 1987, 59, 1990-1995, Cottrell et al.

Affiliated with

Also associated with

Rating

Detection of very large molecular ions in a time-of-flight mass does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of very large molecular ions in a time-of-flight mass , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of very large molecular ions in a time-of-flight mass will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1774431