Detection of venous thromboembolic diseases by measurement...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C436S518000

Reexamination Certificate

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07968302

ABSTRACT:
A method and a test for detecting coagulation activation, in particular when it is responsible for thromboembolic venous diseases; employs assaying D-dimers and assaying the soluble fibrin produced during a fibrinolysis process activated in a blood sample. The method of the invention pertains to comparing the level of D-dimers corresponding to degradation of soluble fibrin and the level of D-dimers of the sample with normal threshold values. The test of the invention may also be used to determine whether anti-coagulation is sufficient in a patient.

REFERENCES:
patent: 5114845 (1992-05-01), Randby
patent: 5206140 (1993-04-01), Marder et al.
patent: 0347933 (1989-12-01), None
patent: 02/18628 (2002-03-01), None
Scott K. Brimble et al., “Evaluation of the Combination of a Bedside D-Dimer Assay and Enzyme-Linked Immunosorbent Soluble Fibrin Assay in Patients with Suspected Venous Thromboembolism”, Thrombosis Research, Nov. 1, 1997, pp. 291-297, vol. 88, No. 3, Elsevier Science Ltd., USA.
Satoshi Ota et al., “Diagnosis of Deep Vein Thrombosis by Plasma-Soluble Fibrin or D-Dimer”, American Journal of Hematology, Aug. 2005, pp. 274-280, vol. 79, No. 4, Wiley-Liss, Inc.
Y.S. Arkel et al., “The use of coagulation activation markers (soluble fibrin polymer, TpPTM, prothrombin fragment 1.2, thrombin-antithrombin, and D-dimer) in the assessment of hypercoagulability in patients with inherited and acquired prothrombotic disorders”, Blood Coagulation and Fibrinolysis, Apr. 2002, pp. 199-205, vol. 13, No. 3, Lippincott Williams & Wilkins.
French Preliminary Search Report and Written Opinion, mailed Dec. 12, 2006 in corresponding French Patent Application No. FR 0604072.
International Search Report dated Sep. 28, 2007, in PCT application.

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