Detection of vascular disease with labelled antibodies

Details Detection of vascular disease with labelled antibodies Detection of vascular disease with labelled antibodies

1988-07-11

1989-10-31

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 858, 514824, 436548, 530402, A61K 4902, A61K 4900, C07K 1700

Patent

active

048775991

ABSTRACT:
Vascular diseases including asymptomatic atherosclerosis can be diagnosed by administering a conjugate diagnostic reagent to a patient and then detecting the location and concentration of the conjugate reagent within the patient's vascular system. The conjugate reagents have a target-seeking, biologically active molecule as one component and a labeling means capable of extracorporeal detection as the other component. The biologically active molecules (BAMs) are chosen to have affinity for structural elements of the arterial wall which are either not present in the normal wall but are found in atherosclerotic or arteritic lesions, or which are not available to the blood-borne reagent within normal arterial walls, but are exposed to the reagent in atherosclerotic or arteriotic lesions.

REFERENCES:
patent: 4116776 (1978-09-01), Dalbow et al.
patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4323546 (1982-04-01), Crockford et al.
patent: 4331647 (1982-05-01), Goldenberg
patent: 4348376 (1982-09-01), Goldenberg et al.
patent: 4359453 (1982-11-01), Gordon
patent: 4427371 (1984-09-01), Burchiel et al.
patent: 4443427 (1984-04-01), Reinherz et al.
patent: 4451570 (1984-05-01), Royston et al.
patent: 4478815 (1984-10-01), Burchiel et al.
patent: 4529694 (1985-07-01), Lazarus et al.
patent: 4577636 (1986-03-01), Spears
patent: 4605413 (1986-08-01), Urry et al.
patent: 4647445 (1987-03-01), Lees
patent: 4660563 (1987-04-01), Lees
patent: 4675287 (1987-06-01), Reisfeld et al.
patent: 4681782 (1987-07-01), Ozkan
Scearce et al., Methods in Enzymology, vol. 103, pp. 459-469 (1983).
Meares et al., Anayltical Biochemistry, vol. 142, pp. 68-78 (1984).
McFarlane, Nature, vol. 182, No. 4267, p. 53.
Zurawski et al., Monoclonal Antibodies (Kennett Ed. 1980), pp. 19-20.
Oi et al., Selected Methods in Cellular Immunology (Mishell Ed. 1980), pp. 353-372.
Khaw et al., Science, vol. 209, pp. 295-297 (1980).
Khaw et al., J. Nuclear Medicine, vol. 23, No. 11 (1982), pp. 1011-1019.
Hnatowich, Science, vol. 220, pp. 613-615 (1983).

Affiliated with

Also associated with

Rating

Detection of vascular disease with labelled antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of vascular disease with labelled antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of vascular disease with labelled antibodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-624579