Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-05-12
1996-04-02
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 795, 435810, 436518, 436811, G01N 3353, G01N 33543
Patent
active
055039863
ABSTRACT:
The method of detecting lower urinary tract disease is disclosed through the comparison of the concentration of a neurotrophic factor present in a urine specimen in comparison with a predetermined normal concentration. Nerve growth factor, having a concentration of approximately less than 8 picograms per milliliter is the preferred factor. The concentration of nerve growth factor in the urine rises at the onset of the lower urinary tract disease and decreases as said disease progresses. Nerve growth factor production and nerve growth is inhibited by administering the Ca.sup.++ channel blockers, verapamil or diltiazem.
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Lodish, H et al. Molecular Cell Biology. New York: Scientific American Books, 1986.
Thomas, C. L. Taber's Cyclopedic Medical Dictionary. F. A. Davis Co., 1985, p. 1123.
Chodak G. W., et al. "Increased levels of Fibroblast Growth. Factor-like Activity in Urine from Patients with Bladder or Kidney Cancer." Cancer Research 48:2083-2088, 1988.
Morrison, R. S. "Fibroblast Growth Factors: Potential Neurotrophic Agents in the Central Nervous System." Journal of Neuorscience Research 17:99-101, 1987.
Nerve Growth Factor in the Urinary Bladder of the Adult Regulates Neuronal Form and Function, W. D. Steers et al, Journal for Clinical Investigations, vol. 88, Nov. 1991, pp. 1709-1715.
Nerve Growth Factor Responsiveness of Cultured Major Pelvic Ganglion Neurons from the Adult Rat, Jeremy B. Tuttle et al, Brain Research, 588 (1992) 29-40.
Calcium Channel Antagonists Prevent Urinary Bladder Growth and Neuroplasticity Following Mechanical Stress, William D. Steers et al, American Physiological Society, 1994, pp. 20-26.
Steers William D.
Tuttle Jeremy B.
Parker Sheldon H.
Parsons Nancy J.
Scheiner Toni R.
University of Virginia Patent Foundation
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