Detection of truncation mutations by mass spectrometry

Details Detection of truncation mutations by mass spectrometry Detection of truncation mutations by mass spectrometry

2004-07-30

2010-10-05

Burkhart, Michael (Department: 1633)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S091200, C435S219000

Reexamination Certificate

active

07807407

ABSTRACT:
This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference.

REFERENCES:
patent: 5478730 (1995-12-01), Alakhov et al.
patent: 6329180 (2001-12-01), Garvin
patent: 7312060 (2007-12-01), Rothschild et al.
patent: 2004/0014071 (2004-01-01), Rothschild et al.
Approximately. (1995). In Roget's II: The New Thesaurus. Retrieved Mar. 13, 2007, from http://www.xreferplus.com/entry/736555.
Genbank Accession CAA26189.
Genbank Accession AAC27645.
Genbank Accession AAL99993.
Genbank Accession NP—001002471.
Genbank Accession AAL99994.
Genbank Accession CAC81278.

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