Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-07-01
2008-07-01
Le, Long (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S110000, C530S356000, C530S840000
Reexamination Certificate
active
10507479
ABSTRACT:
Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
REFERENCES:
patent: 5919634 (1999-07-01), Eyre
patent: 6132976 (2000-10-01), Poole et al.
patent: 2002/0022244 (2002-02-01), Kim et al.
patent: WO96/04311 (1996-02-01), None
patent: WO98/29452 (1998-07-01), None
patent: WO01/38872 (2001-05-01), None
patent: WO 01/84160 (2001-11-01), None
Harlow, E. and Lane, D., Antibodies: A Laboratory Manual (1988) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 23-25 and 76.
Manicourt et al. Chapter 25, “Products of Cartilage Metabolism”, In: Dynamics of Bone and Cartilage Metabolism (2006), Eds. Markus J. Seibel et al., Academic Press, pp. 421-449.
Deberg et al. “New serum biochemical markers (Coll 2-1, and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis” OsteoArthritis and Cartilage (2005) 13, 258-265.
Ter Steege et al. “Nitrotyrosine in Plasma of Celiac Disease Patients as Detected by a New Sandwich ELISA” Free Radical Biology & Medicine (1998) vol. 25, pp. 953-963.
de Vries et al. “Specific localization of IgG isolated from inflamed synovial tissue” Agents and Actions vol. 19 (1986) pp. 5-6.
Khan et a. “3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method” Biochem J. (1998) 330, 795-801.
Lin et al, Chemico-Biological Interaction 127, 2000, pp. 219-236, Nitration and hydoxylation of aromatic amino acid . . . .
Lotz, OSTEOARTHRITIS, vol. 25, No. 2, May 1999, pp. 269-282, The Role of Nitric Oxide in Articular Cartilage Damage.
Moller, Scand J. Clin Lab Invest, 58, 1998, pp. 269-278, Connective tissue markers of rheumatoid arthritis.
Paik et al, Connective Tissue Res, vol. 42(2) , pp. 111-122, 2001, The Nitrite/Collagen Reaction: Non-Enzymatic Nitration . . . .
Soinila et al, Jour of Histochem and Cytochem, vol. 40, No. 2, pp. 231-239, 1992, Immunohistochemistry of Enkephalins: . . . .
Stadtman et al, Anals NY Acad of Sciences, pp. 191-208, 2000, Protein Oxidation.
Wollheim, APMIS 104, 1996, pp. 81-93, Predictors of joint damge in rheumatoid arthritis.
Christgau Stephan
Deberg Michelle
Henrotin Yves
Reginster Jean-Yves
Foster Christine
Jacobson & Holman PLLC
Le Long
Universite de Liege
LandOfFree
Detection of specific nitrated markers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of specific nitrated markers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of specific nitrated markers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3923772