Detection of small molecules by use of a piezoelectric sensor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S070210, C435S287200, C427S427000, C427S099300

Reexamination Certificate

active

07135295

ABSTRACT:
A protein comprising an antigen-binding portion formed by two cooperating peptide sequences of FIGS.3A and3B of the application. The protein may alternatively comprise an altered antigen-binding portion where at least one of the peptide sequences is an altered sequence, an altered sequence being a sequence of FIG.3A or3B in which one or more of an amino acid residue has been added, deleted or replaced by another amino acid residue. The altered antigen-binding portion retains substantially the same antigen-binding specificity as said antigen-binding portion. Also disclosed are apparatus, systems and methods for detecting small assayed molecules in a sample using the protein.

REFERENCES:
patent: 4236893 (1980-12-01), Rice
patent: 4242096 (1980-12-01), Oliveira et al.
patent: 4314821 (1982-02-01), Rice
patent: 4735906 (1988-04-01), Bastiaans
patent: 4999284 (1991-03-01), Ward et al.
patent: 5658732 (1997-08-01), Ebersole et al.
patent: 0 453 224 (1991-10-01), None
patent: WO 97/04314 (1997-02-01), None
patent: WO 98/57141 (1998-12-01), None
Lederman et al, A single amino acid substitution in a common african allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4, 1991, Mol Imm, 28(11), 1171,1181.
Colman, Effects of amino acid sequence changes on antibody-antigen interactions, 1994, Res Imm, 145, 33-36.
Paul W.E. Fundamental immunology, 3rd Edition, 1993, p. 292-295.
Rudikoff et al, Single amino acid substitution altering antigen-binding specificity, Proc. Natl. Acad. Sci. USA 1982 vol. 79: pp. 1979-1983.
Sten-Anders Brink, “Bofors Schnauzer—A Biosensor for Detection of Explosives”,Eurel International Conference: The Detection of Abandoned Land Mines; A Humanitarian Imperative Seeking a Technical Solution,1996, p. 33-36.
Upvan Narang et al., “Multianalyte Detection Using a Capillary-Based Flow Immunosensor”,Analytical Biochemistry,1998, pp. 13-19, vol. 255, article No. AB72411.
Alan Shons et al, “An Immunospecific Microbalance”,J. Biomed, Mater, Res.,1972, pp. 565-570, vol. 6.
Dean D. Fetterolf et al., “An Enzyme-Linked Immunosorbent Assay (ELISA) for Trinitrotoluene (TNT) Residue on Hands”,Journal of Forensic Sciences,1991, pp. 343-349, vol. 36, No. 2.
Hiroshi Muramatsu et al., “Piezoelectric Crystal Biosensor System for Detection ofEscherichia coli”,Analytic Letters,1989, pp. 2155-2166, vol. 22(9).
H. Muramatsu et al., “Piezoelectric Immuno Sensor for the Detection ofCandida albicans Microbes”,Analytica Chimica Acta.,1986, pp. 257-261, vol. 188.
Michael D. Ward et al., “In Situ Interfacial Mass Detection with Piezoelectic Transducers”,Science, 1990, pp. 1000-1007, vol. 249.
Ahmad A. Suleiman et al., “Recent Developments in Piezoelectic Immunosensors: A Review”,Analyst, 1994, pp. 2279-2282, vol. 119.
Joy E. Roederer et al., “Microgravimetric Immunoassay with Piezoelectric Crystals”,Anal. Chem.,1983, pp. 2333-2336, vol. 55.
Hiroshi Muramatsu et al., “Piezoelectric Crystal Biosensor Modified with Protein A for Determination of Immunoglobulins”.,Anal. Chem.,1987, pp. 2760-2763, vol. 59.
Jakob Slanina et al., “Determination of Sulfur Dioxide in Ambient Air by a Computer-Controlled Thermodenuder System”,Anal. Chem.,1987, pp. 2764-2766, vol. 59.
Bernd König et al., “Detection of Viruses and Bacteria with Piezoelectric Immunosensors”,Analytical Letters,1993, pp. 1567-1585, vol. 26(8).
Patent Abstracts of Japan, Publication No. 01269485, Publication date Oct. 26, 1989.
Patent Abstracts of Japan, Publication No. 01269488, Publication date Oct. 26, 1989.
Patent abstracts for DE 3733986, published Apr. 20, 1989.

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