Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-12-14
2010-06-29
Mondesi, Robert (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S514000
Reexamination Certificate
active
07745158
ABSTRACT:
Methods and devices for the detection of proteins secreted by the hyphal growth form ofCandidaspecies are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the speciesCandida, such asC. albicans, for example. The devices of the present invention incorporate antibodies specific to secreted aspartyl protease proteins whose expression is upregulated upon the conversion of theCandidaspecies from the commensal to the pathogenic form. The antibodies may be used in assays to allow the diagnosis of candidal infections and disease conditions. Either monoclonal antibodies or polyclonal antibodies may be used, and in the case of the monoclonals, the specific epitopes of the SAP protein may be detected as well as the SAP protein itself.
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DiGiammarino Enrico L.
McGrath Kevin P.
Phillips Erica M.
Dority & Manning P.A.
Kimberly--Clark Worldwide, Inc.
Mondesi Robert
Shahnan-Shah Khatol
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