Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-06-10
1996-12-17
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303871, 5303879, 5303881, 5303882, 53038822, 5303891, 435 72, 435 721, 435 723, G01N 3353, C07K 1618
Patent
active
055852440
ABSTRACT:
The present invention features peptides derived from RXRX, and antibodies elicited by the peptides. These antibodies bind specifically to RXRX subtypes in its native, functional conformation. Methods are disclosed for detection of RXRX with the antibodies in immunological assays. In addition, this invention describes a hormone-binding immunoprecipitation assay which utilizes both the retinoid receptor subtype specific antibodies and retinoid receptor ligands to detect and measure RXR and RAR subtypes in a sample. A method is also disclosed for determining the profile of retinoid receptor subfamily members with the retinoid receptor ligands.
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Allegretto Elizabeth A.
Pike J. Wesley
Eyler Yvonne
Ligand Pharmaceuticals Incorporated
Scheiner Toni R.
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