Detection of prostate-specific antigen in amniotic fluid, matern

Details Detection of prostate-specific antigen in amniotic fluid, matern Detection of prostate-specific antigen in amniotic fluid, matern

1995-08-01

1997-10-21

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436510, 53038826, 53038885, 5303891, G01N 33573, G01N 33577, C07K 1640

Patent

active

056795343

ABSTRACT:
A method for the evaluation of the condition of a fetus by quantitative measurement of prostate specific antigen (PSA) is provided. In the method, a sample of amniotic fluid or maternal serum is obtained at a gestational week and the sample is assayed for the amount of PSA present. The amount of PSA in the sample is compared with the PSA mean for the given gestational week and evaluated for the risk of a phenotypic and/or genotypic disorder.

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Clinical Biochemistry, vol. 21, No. 3, Jun. 1988, pp. 139-150, Diamandis, E.P., "Immunoassays with Time-Resolved Fluorescence Spectroscopy: Principles and Applications".
Bas. App. Histochem., vol. 33, 1989, pp. 25-29, M. Papotti et al., "Immunocytochemical Detection of Prostate-Specific Antigen (PSA) in Skin Adnexal and Breast Tissues and Tumors".
Eur. J. Clin. Chem. Clin. Biochem. vol. 29, 1991, pp. 787-794, W.G. Wood et al., "The Establishment and Evaluation of Luminescent-Labelled Immunometric Assays for Prostate-Specific Antigen-alpha1-Antichymotrypsin Complexes in Serum".
Clinical Chemistry, vol. 39, No. 10, pp. 2108-2114, H. Yu et al., "Ultrasensitive Time-Resolved Immunofluorometric Assay of Prostate-Specific Antigen in Serum and Preliminary Clinical Studies".

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