Detection of pleiotrophin

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C435S007200, C435S007230

Reexamination Certificate

active

07141384

ABSTRACT:
The invention relates to a novel method and kit for detecting and measuring pleiotrophin in samples and diagnosing pleiotrophin-positive diseases. The method involves incubating a sample suspected of containing PTN with anti-PTN antibodies and determining the presence of PTN using a sandwich ELISA. Also methods for treating a pleiotrophin-positive disease by administering an anti-PTN antibody or fragment thereof are provided.

REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: WO 96/02257 (1996-02-01), None
patent: WO 99/07407 (1999-02-01), None
Choudhuri et al Cancer Research vol. 57 p. 1814 (1997).
Yolken, Reviews of Infectious Disease vol. 4 p. 35 (1982).
Milstein et al Nature vol. 256 p. 495 (1975).
Ichikawa et al., A highly sensitive enzyme immunoassay for G-CSF in human plasma, Exp Hematol., Mar. 1995; 23 (3) :192-5, abstract only.
Helle et al., “Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids; synovial fluids and sera”, J Immunol Methods., Apr. 8, 1991; 138 (1): 47-56, abstract only.
Morita et al., “Development of a sensitive enzyme-linked immunosorbent assay for eotaxin and measurement of its levels in human blood”, J Immunol Methods., Jun. 24, 1999; 226 (1-2): 159-67, abstract only.
van der Pouw Kraan et al., “Characterisation of monoclonal antibodies to human IL-4: application in an IL-4 ELISA and differential inhibition of IL-4 bioactivity on B cells and T cells”, Eur Cytokine Netw., Sep.-Oct. 1993; 4 (5): 343-9, abstract only.
Ida et al., “A highly sensitive enzyme-linked immunosorbent assay for the mesaurement of interleukin-8 in biological fluids”, J Immunol Methods., Nov. 25, 1992; 156 (1): 27-38, abstract only.
De Groote et al., “Characterisation of monoclonal antibodies against human interleukin-10 and their use in an ELISA for the measurement of this cytokine”, J Immunol Methods., Dec. 28, 1994; 177 (1-2): 225-34, abstract only.
Kiss et al., “Determination of IL6, IL1, and IL4 in the plasma of patients with multiple myeloma”, Leuk Lymphoma., Jul 1194; 14 (3-4): 335-40, abstract only.
Fukuda et al., “A sandwich enzyme-linked immunosorbent assay for human interleukin-5”, J Immunol Methods., Sep. 20, 1992; 143 (1): 89-94, abstract only.
Ida et al., “An enyzme-linked immunosorbent assay for the measurement of human interleukin-6”, J Immunol Methods., Oct. 19, 1990; 133 (2); 279-84, abstract only.
Adolf, GR, “Monoclonal antibodies and enzyme immunoassays specific for human interferon (IFN) omega 1: evidence that IFN-omega 1 is a component of human leukocyte IFN”, Virology, Apr. 1990; 175 (2): 410-7. abstract only.
Ellis et al., “Capture immunoassay for ruminant tumor necrosis factor-alpha: comparison with bioassay,” Vet Immunol Immunopathol., Jan. 1993; 35 (3-4): 289-300, abstract only.
Petyovka et al., “Homologous ELISA for detection of oligomeric human TNF: properties of the assay,” J. Immunol Methods., Oct. 26, 1995; 186 (2): 161-70, abstract only.
van der Meide et al., “A sensitive two-site enzyme immunoassay for the detection of rat interferon-gamma in biological fluids.” J. Interferon Res., Apr. 1990; 10 (2): 183-9, abstract only.
Nan Zhang et al., “Human Breast Cancer Growth Inhibited in Vivo by a Dominant Negative Pleiotrophin Mutant”, The Journal of Biological Chemistry, vol. 272 ( No. 27), pp. 16733-16736, (Jul. 4, 1997).
International Search Report for International Patent Application No. PCT/US99/23220, mailed on Feb. 4, 2000.
Supplementary European Search Report for European Patent Application No. 99951799.8, mailed on Dec. 17, 2001.
Beau et al., 1995, “Retinoic acid-induced heparin binding protein (RIHB) binds to embryonal chondrocytes and cartilage primarily via proteoglycans”, Exp. Cell Res., 218(2):531-539 (abstract only).
Brigstock et al., 1996, “Pig uterine luminal fluid contains the developmentally regulated neurotophic factor, pleiotrophin”, J. Endocrinology, 148(1):103-111 (abstract only).
Choudhuri et al., 1996, “The neurotophins midkine and pleiotrophin are angiogenic and promote tumour growth”, Proc. Am. Assoc. for Cancer Research 37:57-58, abstract # 400.
Czubayko et al., 1994, Ribozyme-targeting Elucides a Direct Role of Pleiotrophin in Tumor Growth:, J. Biol. Chem., 269(33):21358-21363.
Dreyfus et al., 1998, “Pleiotrophin: Localizaiton of mRNA and protein in the chicken developing leg”, Int'l. J. Dev. Biol., 42(2):189-198 (abstract only).
Fang et al., 1992, “Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer”, J. Biol. Chem. 267(36):25889-25897.
Harris et al. , 1994, “Breast cancer angiogenesis-major independent prognostic factor in node negative breast cancer, regulation by multiple angiogenic factors”, Proc. Am. Assoc. for Cancer Research 35:185, abstract #1106.
Mitsiadis et al., 1995, “Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis”, Development, 121(1):37-51 (abstract only).
Obama et al., 1995, “Midkine (MK) expression in extraembryonic tissues, amniotic fluid, and cerebrospinal fluid during mouse embryogenesis”, J. Biochem., 118:88-93.
Reigel et al., 1994, “The potential role of the heparin-binding growth factor pleiotrophin in breast cancer”, Breast Cancer Res. Treat., 31(2-3):309-314 (abstract only).
Schulte et al., 1996, “Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line Insertion of an endogenous retrovirus”, Proc. Natl. Acad. Sci., USA, 93:14759-14764.
Souttou et al., 1998, “Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumors”, J. Nat'l. Cancer Inst., 90(19):1468-1472.
Zhang et al., 1999, “Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors”, Current Opinion in Hem., 6(1):44-50.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Detection of pleiotrophin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of pleiotrophin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of pleiotrophin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3645513

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.