Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Reexamination Certificate
2006-05-02
2006-05-02
Woitach, Joseph (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
C800S003000, C424S009100, C424S009200
Reexamination Certificate
active
07038106
ABSTRACT:
The present invention discloses an in situ method of screening a compound for pharmacological activity comprising the steps of detecting an initial pattern of neural activity in brain tissue, adding the compound to the brain tissue and detecting a resulting pattern of neural activity, and observing the pharmacological activity of the compound on neural activity by comparing the initial pattern of intracellular neural activity with the resulting pattern of neural activity.
REFERENCES:
patent: 5714666 (1998-02-01), Pritchett et al.
patent: 5777195 (1998-07-01), Fienberg et al.
patent: 0 713 092 (1996-05-01), None
patent: WO93/15184 (1993-05-01), None
Duffy et al.; Adrenergic Calcium Signaling in Astrocyte Networks within the Hippocampal Slice; The Journal of Neuroscience, Aug. 1995, 15(8): 5535-5550.
O'Brochta et al.; Recent Developments in Transgenic Insect Technology; Parasitology Today vol. 13, No. 3, 1997; pp. 99-104.
Cameron. Recent Advances in Transgenic Technology. Molec. Biotech. 1977, vol. 7, pp. 253-265.
Sigmund. Viewpoint: Are Studies on Geneically Altered Mice Out of Control? Arterioscler. Thromb. Vasc. Biol. 2000, vol. 20, pp. 1425-1429.
Nieman. Transgenic Farm Animals Get Off the Ground. Transgenic Research. 1998, vol. 7, pp. 73-75.
Bal et al., J. Neurophysiology, 77(6):3145-3156, Jun. 1997.
Izu, Leighton T.,A Class of Parametrically Excited Calcium Oscillation Detectors, Biophysical Journal, vol. 68, pp. 1621-1629 (Apr. 1995).
Chay, Teresa Ree,Electrical bursting and luminal calcium oscillation in excitable cell models, Biological Cybernetics, pp. 419-431 (1996).
Fan, Yin-Shui, et al.,Generation of periodic and chaotic bursting in an excitable cell model, Biological Cybernetics, vol. 71, No. 5, pp. 417-421 (1994).
Rosay, Philippe, et al.,Cell-type specific calcium signalling in a Drosophila epithelium, Journal of Cell Science, vol. 110, pp. 1683-1692 (1997).
Dani et al., “The triggering of astrocytic calcium waves by NMDA-induced neuronal activation”,Ciba Found Symp., 188:195-205 (1995).
Grapengiesser et al., “Glucose-Induced Oscillations of Cytoplasmic Ca2+in the Pancreatic β-Cell”,Biochemical and Biophysical Research Communications, 151(3):1299-1304 (1988).
Grapengiesser, “Glucose Induces Cytoplasmic Na+Oscillations in Pancreatic β-Cells”,Biochemical and Biophysical Research Communications, 226:830-835 (1996).
Gu et al., “Pharmacological Analysis of Heartbeat inDrosophila”, Journal of Neurobiology, 28(3):269-280 (1995).
Rohr et al., “Multiple Site Optical Recording of Transmembrane Voltage (MSORTV) in Patterned Growth Heart Cell Cultures: Assessing Electrical Behavior, with Microsecond Resolution, on a Cellular and Subcellular Scale”,Biophysical Journal, 67:1301-1315 (1994).
Wang et al., “Mechanism of synchronized Ca2+oscillations in cortical neurons”,Brain Research, 767:239-249 (1997).
Woods et al., “Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes”,Nature, 319:600-602 (1986).
Armstrong James Douglas
Kaiser Kim
Rosay Philippe
Dann Dorfman Herrell and Skillman
Rigaut Kathleen D.
The University Court of the University of Glasgow
Woitach Joseph
LandOfFree
Detection of neural activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of neural activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of neural activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3636263