Detection of neoplasms by hormonal tumor stimulation test

Details Detection of neoplasms by hormonal tumor stimulation test Detection of neoplasms by hormonal tumor stimulation test

1994-02-24

1996-12-10

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

436 64, 436 86, A61K 3808, G01N 3368, G01N 3374

Patent

active

055831109

ABSTRACT:
A method for screening for cancer, a cancer test, a screening system a patient monitoring system and medicinal dosage form for measuring stimulating a specific, detectable response from a stimulus-responsive neoplasm, comprising administering a neoplasm-affecting treatment, in sufficient quantity to stimulate the response; and drawing a blood sample at a time after administration sufficient to distinguish the response. Administering a GnRH analog to a woman prior to measuring circulating serum tumor markers for ovarian epithelial carcinoma provides an improved screening result.

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Mayer et al. Obstetrics and Gynecology 75(3);529-531. Mar. 1990.
Barbot et al. "Pentagastrin Stimulation Test and Early Diagnosis of Medullary Thyroid Carcinoma . . . "J. Clin. Endocrinology and Metabolism. 78(1):114-120. 1994.
Leung et al. "Intercellular Signaling in thte Gonads", Endocrine Reviews. 13(3):476-498. Aug. 1992.
Ohno et al. "Presence of gonadotropin-releasing hormone and its messenger ribonucleic acid in human ovarian epithelial carcinoma", Am J Obstet Gynecol. 169(3): 605-611. 1993.
Adelson et al. "Effects of Gonadotropin-Releasing Hormone Analogues on Ovarian Epithelial Tumors", Clin. Obstetrics and Gynecology. 36(3):690-700. Sep. 1993.
Emons et al. "Gonadotropin Releasing Hormone Binding Sites in Human Epithelial Ovarian Carcinomata", Eur J Cancer Clin Oncol. 25:215-221. 1989 .

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