Detection of necrotic malignant tissue and associated therapy

Details Detection of necrotic malignant tissue and associated therapy Detection of necrotic malignant tissue and associated therapy

1989-02-23

1991-05-28

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 8591, 530389, 530387, A61K 4300, A61K 4902, A61K 3900, C07K 1528

Patent

active

050193686

ABSTRACT:
Disclosed is a method for enhancing the effects of therapy that kills malignant cells in vivo comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of a mammal but not to external cellular components, wherein the monoclonal antibody is attached to an antineoplastic agent; initiating therapy in a mammal to kill malignant cells in vivo, thereby causing some of the malignant cells to become necrotic; and administering the antibodies to the mammal. The antibodies bind to the necrotic malignant cells thereby delivering antineoplastic agent to surrounding cells. Also disclosed is a method of de novo therapy comprising administration of antibody-antineoplastic agent conjugate such that antineoplastic agent is delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods and for use with diagnositc methods.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4361544 (1982-11-01), Goldenberg
patent: 4460559 (1984-07-01), Goldenberg
patent: 4460561 (1984-07-01), Goldenberg
patent: 4499183 (1985-02-01), Sujarsky et al.
patent: 4613576 (1986-09-01), Cote et al.
patent: 4628027 (1986-12-01), Gay
patent: 4699877 (1987-10-01), Cline et al.
patent: 4735210 (1988-04-01), Goldenberg
patent: 4861581 (1989-08-01), Epstein et al.
Chem. Abstracts 107(7):57118b, 1987, S. Welt et al., "Monoclonal Antibody to an Intracellular Antigen . . . " PNAS 84(12), 4200-4204.
Cater et al., Inflammatory Changes in Tumour Vessels .Aafter Systemic 5-Hydroxytryptamine, Bradykinin, Kallikrein, or Lysolecithin. Br. J. Cancer 20:517-525, 1966.
Thomlinson et al., The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy, Br. J. Cancer 9:539-549, 1955.
Morgan et al., Monoclonal Antibody Therapy of Cancer: Preclinical Models and Investigations in Humans, In: R. Herberman (ed).
Cancer Immunology: Innovative Approaches to Therapy, pp. 177-200, Boston, Mass: Martinus Nijhoff Publishers, 1986.
Cooper et al., Cell Death in Normal and Malignant Tissues, Adv. Cancer Research, 21:59-120, 1975.
Khaw et al., Myocardial Damage Delineated by Indium-111 Antimyosin Fab and Technetium-99m Pyrophosphate, Science 209-295-297, 1980.
G. G. Steel, "Cell Loss as a Factor in the Growth Rate of Human Tumours", pp. 381-387.
I. F. Tannock, "The Relations Between Cell Proliferation and the Vascular System in a Transplanted Mouse Mammary Tumour," pp. 258-272.
E. H. Cooper, "The Biology of Cell Death in Tumours," Cell Tissue Kinet., pp. 87-95 (1973).
Epstein, A. and Clevenger, C. in Progress in Non-Histone Protein Research, I. Bekhor (Ed.), CRC Press, Boca Raton, 1985, pp. 117-137.
Clevenger, C. and Epstein, A. (1984) Exper. Cell Res. 151, 194-207.
Clevenger, C. and Epstein, A. (1984) J. of Histochem. and Cytochem., 32(7) 757-765.
Beller, G. et al. (1977) Circulation 55(1), 74-78.
Murao, S. et al., (1985) Cancer Res. 45, 791-795.
Bauer, K. et al. (1986) J. of Histochem. and Cytochem. 34(2) 245-250.
Clevenger, C et al. (1985) Cytometry 6, 208-214.
Bauer, K. et al. (1986) Cancer Res. 46, 2428-2434.
Ghose, T. et al. (1975) Europ. J. Cancer 11, 321-326.
Pelham, J. et al. (1983) Cancer Immunol. Immunother. 15, 210-216.
Deguchi, T. et al. (1986) Cancer Res. 46, 3751-3755.
Hurwitz, E. et al. (1975) Cancer Res. 35, 1175-1181.
Marcholonis J. (1969) Biochem. J. 113, 299-305.
Khaw, B. et al. (1976) J. Clin. Invest. 58, 439-446.
Khaw, B. et al. (1979) Circulation 60, 1527-1531.
Centocor: Product Brochure (SNM 1986) "Cardiac Patient Management".
Centocor: Product Brochure (SNM 1986) "Tumor Imaging with Monclonal Antibodies: Ovarian and Breast CA.".
Centocor: Product Brochure (SNM 1986) "Thrombus Detection with Monoclonal Antibodies".

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