Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-09-02
1999-09-28
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 18, 435 19, 435 912, 435 94, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 536 245, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
059586923
ABSTRACT:
Methods are disclosed for detecting one or more mutations in an isolated test nucleic acid by forming a heteroduplex with a homologous control DNA and contacting the heteroduplex with a resolvase capable of recognizing at least one single base pair mismatch within the heteroduplex. In preferred embodiments of the invention, the resolvase is bacteriophage T4 endonuclease VII.
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Cotton Richard G. H.
Kemper Borries W.
Youil Rima
Fredman Jeffrey
Variagenics Inc.
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