Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-10-20
1996-02-27
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 9152, 935 77, 935 78, C12Q 168, C12P 1934
Patent
active
054947944
ABSTRACT:
This invention provides a method of Alzheimer's disease and/or Parkinson's Disease. The method comprises detecting in a sample from a subject the presence of a mutation, for example, in nucleotide position 4,336, 3,397, 3,196 or an insertion between positions 956 and 965, of mitochondrial DNA. The presence of the mutation indicates the presence of or a predisposition to Alzheimer's and Parkinson's disease. Since each mutation increases the likelihood of developing or having Alzheimer's and Parkinson's disease, the detection of more than one of the mutations in an individual can increase the probability of having or developing the disease. The invention also provides a method of determining mutations associated with the presence of or predisposition to Alzheimer's and/or Parkinson's disease. The method comprises:
(a) obtaining a mitochondrial DNA-containing sample from a subject with Alzheimer's and Parkinson's disease;
(b) determining the presence of mutations in the mitochondrial DNA;
(c) comparing the mutations to mutations found in a normal subject; and
(d) determining which mutations have a greater rate of occurrence in the subject with Alzheimer's and Parkinson's disease.
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Emory University
Horlick Kenneth R.
Parr Margaret
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