Detection of MECT1-MAML2 fusion products

Details Detection of MECT1-MAML2 fusion products Detection of MECT1-MAML2 fusion products

2007-05-08

2007-05-08

Qian, Celine (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C435S007100, C435S040500

Reexamination Certificate

active

10479546

ABSTRACT:
The present invention provides methods and compositions for the diagnosis and treatment of cancer, including cancers involving the NOTCH pathway. In particular, the present invention provides methods and compositions for the diagnosis of mucoepidermoid carcinoma, the most common malignant salivary gland tumor. The present invention further provides methods and compositions for the diagnosis of other tumors associated with the t(11;19)(q14–21;12–13) translocation.

REFERENCES:
patent: 5567586 (1996-10-01), Croce
patent: 5637471 (1997-06-01), Artavanis-Tsakonas et al.
patent: 5786158 (1998-07-01), Artavanis-Tsakonas et al.
patent: 6083904 (2000-07-01), Artavanis-Tsakonas
patent: 6130043 (2000-10-01), Billing-Medel et al.
patent: 6174674 (2001-01-01), Morris et al.
El-Naggar et al. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet. vol. 87, No. 1, pp. 29-33, Mar. 1996.
Toida et al. Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization. Cancer Genet Cytogenet. vol. 127, No. 1, pp. 34-37, May 2001.
Kirchhoff et al. High resolution comparative genomic hybridisation in clinical cytogenetics. J Med Genet. vol. 38, No. 11, pp. 740-744, Nov. 2001.
Nordkvist et al. Cytogenetic observations in 13 cystadenolymphomas (Warthin's tumors). Cancer Genet Cytogenet. vol. 76, No. 2, pp. 129-135, Sep. 1994.
Nordkvist et al. Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma. Cancer Genet Cytogenet. vol. 74, No. 2, pp. 77-83, Jun. 1994.
Behboudi et al. Molecular classification of mucoepidermoid carcinomas-Prognostic significance of the MECT-MAML2 fusion oncogene. Genes Chromosomes Cancer. vol. 45, No. 5, pp. 470-481, May 2006.
Kroese et al. Genetic tests and their evaluation: can we answer the key questions? Genet Med. vol. 6, pp. 475-480, 2004.
Stenman et al. A child with a t(11;19)(q14-21;p12) in a pulmonary mucoepidermoid carcinoma. Virchows Arch. vol. 433, No. 6, pp. 579-581, Dec. 1998.
Bullerdiek et al. Translocation t(11;19)(q21;p13.1) as the sole chromosome abnormality in a cystadenolymphoma (Warthin's tumor) of the parotid gland. Cancer Genet Cytogenet. vol. 35, No. 1, pp. 129-132, Oct. 1988.
AP000865.2, GI: 8119013, publicly available May 30, 2000.
AC011875.3, GI: 7107950, publicly available Mar. 12, 2000.
Nasedkina et al. Identification of chromosomal translocations in leukemias by hybridizatin with oligonucleotide microarrays. Haematologica, vol. 87, No. 4, pp. 363-372, Apr. 2002.
Rogan et al. Sequence-based design of single-copy genomic DNA probes for fluorescence in situ hybridization. Genome Research, vol. 11, No. 6, pp. 1086-1094, Jun. 2001.
von Bergh et al. A DNA probe combination for imprived detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias. Genes, Chromosomes & Cancer, vol. 28, pp. 14-22, 2000.
Allman et al., “An Invitation to T and More: Notch Signaling in Lymphopoiesis,”Cell, vol. 109, pp. S1-S11 (2002).
Artavanis-Tsakonas et al., “Notch Signaling,”Science, vol. 268, pp. 225-232.
Aster et al., “Notch Signaling in Leukemia,”Curr. Opin. Hematol., vol. 8, pp. 237-244 (2001).
Aster et al., “Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1,”Mol. Cell. Biol., vol. 20 (20), pp. 7505-7515 (2000).
Calcaterra, “Salivary Glands,”Cancer Treatment, 4thed.(Haskell, ed.),W.B. Saunders Company, Philadelephia, Chapter 62, pp. 721-726 (1995).
Carney et al., “Establishment and Identification of Small Cell Lung Cancer Cell Lines Having Classic and Variant Features,”Cancer Res., vol. 45, pp. 2913-2923 (1985).
Dahlenfors et al., “Translocation(11:19)(q14-21;P12) in a Parotid Mucoepidermoid Carcinoma of a Child,”Cancer Genet. Cytogenet., vol. 79, p. 188 (1995).
Dahlenfors et al., “A Fourth Minor Salivary Gland Mucoepidermoid Carcinoma with 11q14-21 and 19p12 Rearrangements,”Hereditas, vol. 120, pp. 287-288 (1994).
GenBank Assession No. AB014516, May 26, 1998.
GenBank Accession No. AB058772, Mar. 27, 2001.
GenBank Accession No. AE003523, Mar. 21, 2000.
GenBank Accession No. AF221759, Jan. 6, 2000.
GenBank Accession No. AK024089, Aug. 23, 2000.
GenBank Accession No. AY040322, Jun. 14, 2001.
GenBank Accession No. BAA31591, May 26, 1998.
GenBank Accession No. BAB47448, Mar. 27, 2001.
GenBank Accession No. NM—025021, (2003).
GenBank Accession No. NT—008984, (2003).
GenBank Accession No. X54251, Aug. 8, 1990.
GenBank Accession No. XM—011324, May 9, 2002.
GenBank Accession No. XM—045716, (2003).
GenBank Accession No. XM—059064, Feb. 6, 2002.
Horsman et al., “Translocation (11:19)(q21;p13.1) in Mucoepidermoid Carcinoma of Salivary Gland,”Cancer Genet. Cytogenet., vol. 80, pp. 165-166 (1995).
Hsieh et al., “Truncated Mammalian Notch1 Activated CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr virus EBNA2,”Mol. Cell. Biol., vol. 16 (3), pp. 952-959 (1996).
Jin et al., “Characterization of Chromosome Aberrations in Salivary Gland Tumors by FISH, Including Multicolor COBRA-FISH,”Genes Chromosomes Cancer, vol. 30, pp. 161-167 (2001).
Johansson et al., “Translocation 11;19 in a Mucoepidermoid Tumor of the Lung,”Cancer Genet. Cytogenet., vol. 80, pp. 85-86 (1995).
Kas et al., “Promoter Swapping Between the Genes for a Novel Zinc Finger Protein and β-catenin in Pleiomorphic Adenomas with t(3;8)(p21;q12) Translocations,”Nat. Genet., vol. 15, pp. 170-174 (1997).
Kojika et al., “Notch Receptors and Hematopoiesis,”Exp. Hematol., vol. 29, pp. 1041-1052 (2001).
Martins et al., “Cytogenic Characterisation of Warthin's Tumour,”Oral Oncol., vol. 33 (5), pp. 344-347 (1997).
Martins et al., “Malignant Salivary Gland Neoplasms: a Cytogenetic Study of 19 Cases,”Oral Oncol., Eur. J. Cancer, vol. 32B (2), pp. 128-132 (1996).
Mitelman, “Recurrent Chromosome Aberrations in Cancer,”Mutat. Res., vol. 462, pp. 247-253 (2000).
Modi et al., “Protein Expression of the RB-related Gene Family and SV40 Large T Antigen in Mesothelioma and Lung Cancer,”Oncogene, vol. 19, pp. 4632-4639 (2000).
Petcherski et al., “Mastermind is a Putative Activator for Notch,”Curr. Biol., vol. 10 (13), pp. R471-R473 (2000).
Petcherski et al., “LAG-3 is a Putative Transcriptional Activator in theC. elegansNotch Pathway,”Nature, vol. 405, pp. 364-368 (2000).
Schoenmakers et al., “Recurrent Rearrangements in the High Mobility Group Protein Gene,HMGI-C, in Benign Mesenchymal Tumours,”Nat. Genet., vol. 10, pp. 436-444 (1995).
Tonon et al., “Spectral Karyotyping Combined with Locus-Specific FISH Simultaneously Defines Genes and Chromosomes involved in Chromosomal Translocations,”Genes Chromosomes Cancer, vol. 27, pp. 418-423 (2000).
Vokes et al., “Head and Neck Cancer,”New Eng. J. Med., vol. 328 (3), pp. 184-194 (1993).
Wu et al., “MAML1, a Human Homologue ofDrosophilaMastermind, is a Transcriptional Co-Activator for NOTCH Receptors,”Nat Genet., vol. 26, pp. 484-489 (2000).
Xu et al., “TheNotchLocus and the Genetic Circuitry Involved in EarlyDrosophilaNeurogenesis,”Genes Dev., vol. 4, pp. 464-475 (1990).
Kaye et al., “Emerging Biology of Malignant Salivary Gland Tumors Offers New Insights into the Classification and Treatment of Mucoepidermoid Cancer,”Clin Cancer Res. vol. 12 (13), pp. 3878-3881 (2006).
Martins et al., “A Study of MECT1-MAML2 in Mucoepidermoid Carcinoma and Warthin's Tumor of Salivary Glands,”Journal of Molecular Diagnostics, vol. 6 (3), pp. 205-210 (2004).
Okabe et al., “MECT1-MAML2 Fusion Transcript Defines a Favorable Subset of Mucoepidermoid Carcinoma,”Clin Cancer Res, vol. 12 (13), pp. 3902-3907 (2006).
GenBank Accession No. AB058719, Mar. 27, 2001.

Affiliated with

Also associated with

Rating

Detection of MECT1-MAML2 fusion products does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of MECT1-MAML2 fusion products, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of MECT1-MAML2 fusion products will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3799692