Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1999-02-02
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303888, 53038885, 435326, 435366, 435 724, 436548, 536 2353, C07K 1630, C12N 508
Patent
active
058666907
ABSTRACT:
Described herein is the production of two products which are distinct species of human anti-malignin antibody, and the production of a cell line which has the distinguishing characteristic of manufacturing both species of anti-malignin antibody at different times. These anti-malignin products are useful to detect the presence of cancerous or malignant tumor cells. Additionally, these anti-malignin products preferentially attach to cancerous or malignant tumor cells in cell collections in vitro or in vivo and thus can be detected by any visible or other signal emitter attached to said anti-malignin product. This preferential attachment to malignant tumor cells also makes these products useful for metabolic and therapeutic purposes with or without an attached cytotoxic agent.
REFERENCES:
patent: 4298590 (1981-11-01), Bogoch
patent: 4486538 (1984-12-01), Bogoch
Hansson, et al., J. Exp. Med., vol. 158, pp. 616-622, Aug. 1983.
Watson, et al., J. Immunology, vol. 130, No. 5, pp. 2442-2447, May 1983.
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