Detection of lymphocyte amplification

Details Detection of lymphocyte amplification Detection of lymphocyte amplification

1989-04-13

1992-05-12

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 4352401, 4352402, 436501, 436506, 436 63, 436 94, 935 77, 935 78, C12Q 168, G01N 3353, G01N 33566, G01N 3348

Patent

active

051127350

ABSTRACT:
A method for detecting lymphocyte clonal amplification in a mammal by cloning of lymphocytes so as to identify cell lines expressing a mutation at a structural locus and determining the structure of the antigen receptor in the mutated clonal cell lines. Similar rearrangements of the regions of nucleic acid encoding antigen receptor among multiple isolated clones from a single individual indicate an in vivo clonal lymphocyte amplification event.

REFERENCES:
patent: 4066510 (1978-01-01), Thilly
patent: 4544632 (1985-10-01), Yamamura et al.
patent: 4647535 (1987-03-01), Ritts, Jr.
Abertini et al., (1982) PNAS, U.S.A. 79:6617-6621.
Yanagi et al., (1984) Nature, 308:145-149.
Yang et al., (1984) Nature, 310:412-414.
Albertini et al., (1985) Nature, 316:369-371.
Nicklas, J., O'Neill, Patrick, and Albertini, Richard J. 1986, Use of T-Cell Receptor Gene Probes to Qualify the in Vivo Hprt Mutations in Human T-Lymphocytes, Mutation Res. 173:67-72.

Affiliated with

Also associated with

Rating

Detection of lymphocyte amplification does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of lymphocyte amplification, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of lymphocyte amplification will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2426037