Detection of loss of the wild-type P53 gene and kits therefor

Details Detection of loss of the wild-type P53 gene and kits therefor Detection of loss of the wild-type P53 gene and kits therefor

1993-03-22

1996-06-18

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435810, 436501, 436 63, 514 44, 536 231, 536 241, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168, C07H 2104

Patent

active

055276768

ABSTRACT:
Methods and kits are provided for assessing mutations and/or loss of the p53 gene in human tumors. Both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor. Loss of wild-type p53 genes is responsible for neoplastic progression.

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