Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-03-14
2006-03-14
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S007210, C435S004000, C435S287200, C435S288700, C436S501000, C436S518000, C436S524000, C436S527000, C436S528000, C436S535000, C422S068100, C422S081000, C422S091000
Reexamination Certificate
active
07011948
ABSTRACT:
Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i.e., properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.
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Balaban David
Chapman Robert G.
Ghanouni Pejman
Heanue Joseph A.
May Andrew P.
Horlick Kenneth R.
Howard Kelvan Patrick
MDS Sciex
Neeley Richard
Tung Joyce
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