Detection of hypoxia with reagents containing 2-nitroimidazole c

Details Detection of hypoxia with reagents containing 2-nitroimidazole c Detection of hypoxia with reagents containing 2-nitroimidazole c

1994-08-04

1996-07-30

Kim, Kay K. A.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 149, 424 189, 424 937, 4241811, 4241751, 422 61, 436547, 530362, 530403, 530404, 530405, 5483381, A61K 5110, A61K10102, A61K 31415, G01N 33531, C07D23391, C07K 1618

Patent

active

055409083

ABSTRACT:
Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

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