Detection of hypoxia

Details Detection of hypoxia Detection of hypoxia

1996-02-08

1998-12-01

Achutamurth, Ponnathamurthy

Drug, bio-affecting and body treating compositions

In vivo diagnostic or in vivo test agent which contains an...

424149, 424189, 424937, 4241741, 4241841, 5303871, 5303911, A61K 5110, A61K10102, A61K 31415, G01N 33531

Patent

active

058434046

ABSTRACT:
Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

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