Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-11-04
1997-08-26
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 912, 536 243, 536 2432, C12Q 170, C12Q 168, C12P 1934, C07H 2104
Patent
active
056609795
ABSTRACT:
A method for determining virus replication in human cells by human retrovirus using RNA amplification comprising detecting the hybridization of an RNA probe which specifically hybridizes with spliced RNA and not with genomic RNA. This method permits early detection of RNA replication resulting from primary infection without detecting non-replicating virus.
REFERENCES:
patent: 5118605 (1992-06-01), Urdea et al.
Furtado et al, Analysis of Alternatively Spliced Human Immunodeficiency Virus Type-1 mRNA Species, One of Which Encodes a Novel TATENV Fusion Protein, Virology 185:258-270, 1991.
Smith et al, J. of General Virology 73:1825-1828, 1992.
Peng and Haase, Annu Conf. Australias Soc, HIV Med, 5, p. 109, 1993, meeting abstract.
Lewis et al., Prog. Med. Virol., 40:19-47, 1993.
Meylan et al., Virology, 193:138-148, 1993.
M. Arens et al., "Alterations in Spliced nd Unspliced HIV-1 Specific RNA Detection in Peripheral Blood Mononuclear Cells of Individuals with Varying CD4-Positive Lymphocyte Counts," Aids Research and Human Retroviruses, 9:12:1257-1263, 1993.
R. Boom et al., "Rapid and Simple Method for Purification of Nucleic Acids," Journal of Clinical Microbiology, 28:3:495-503, Mar. 1990.
R. Balachandran et al., "Human Immunodeficiency Viirus Isolates from Asymptomatic Homosexual Men and from AIDS Patients Have Distinct Biologic and Genetic Properties," Virology, 180:229-238 (1991).
D.J. Capon et al., "The CD4-gp120 Interaction and AIDS Pathogens," Ann. Rev. Immun., vol. 9: pp. 649-678, 1991.
D.S. Dimitrov et al., "Quantitation of Human Immunodeficiency Virus Type 1 Infection Kinetics," Journal of Virology, 67:4:2182-2190, Apr. 1993.
E.M. Fenyo et al., "Distinct Replicative and Cytopathic Characteristics of Human Immunodeficiency Virus Isolates" Journal of Virology, 62:11:4414-4419, Nov. 1988.
M.A. Fischl et al., "The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex," The New England Journal of Medicine, 317:4:185-191, Jul. 23, 1987.
T. Kievits et al., "NASBA isothermal enzymatic in vitro nucleic acid amplification optimized for the diagnosis of HIV-1 infection," Journal of Virological Methods, 35:273-286, 1991.
S. Laal et al., "A Rapid, Automated Microtiter Assay for Measuring Neutralization of HIV-1," AIDS Research and Human Retroviruses, 9:781-785, 1993.
T.J. Matthews et al., "Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein," Proc. Natl. Acad. Sci., USA, 83:9709-9713, Dec. 1986.
P.L. Nara et al., "Simple, Rapid, Quantatative, Syncytium-Forming Microassay for the Detection of Human Immunodeficiency Virus Neutralizing Antibody," AIDS Research and Human Retroviruses, 3:3:283-302, 1987.
R. Pal et al., "Characterization of a Neutralizing Monoclonal Antibody to the External Glycoprotein of HIV-1," Intervirology, 86:86-93, 1992.
M.L. Robb et al., "HIV Neutralization Assay Using Polymerase Chain Reaction-Derived Molecular Signals," Journal of Aquired Immune Deficiency Syndromes 5:1224-1229, 1992.
M. Robert-Guroff et al., "HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex," Nature, 316:72-74, Jul. 4, 1985.
Z.F. Rosenberg et al., "Immunopathogenesis of HIV Infection," The FASEB Journal, 5:2382-2390, Jul. 1991.
K. Saksela et al., "Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4.sup.+ lymphocytes," Proc. Natl. Acad. Sci., USA, 91:1104-1108, Feb. 1994.
H. Schuitemaker et al., "Monocytotropic Human Immunodeficiency Virus Type 1 (HIV-1) Variants Detectable in all stages of HIV-1 Infection Lack T-Cell Line Tropism and Syncytium-Inducing Ability in Primary T-Cell Culture," Journal of Virology, 65:1:356-363, Jan. 1991.
B. van Gemen et al., "Quantification of HIV-1RNA in plasma using NASBA during HIV-1 primary infection," Virological Mehtods, 43:177-188, 1993.
M. Tersmette et al., "Differential Syncytium-Inducing Capacity of Human Immunodeficiency Virus Isolates: Frequent Detection of Syncytim-Inducing Isolates in Patients with Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex," Journal of Virology, 62:6:2026-2032, Jun. 1988.
B. van Gemen et al., "A one-tube quantitative HIV-1 RNA NASBA nucleic acid amplification assay using electrochemiluminescent (ECL) labeled probes," Journal of Virological Methods, 49:157-168, 1994.
L. Ratner, "Molecular biology and pathogenesis of HIV infection," Current Opinion in Infectious Diseases, 6:181-190, 1993.
C. Cheng-Mayer, "Biological and molecular features of HIV-1 related to tissue tropism," AIDS, 4 (Sup. 1):540-556.
Pal Ranajit
Romano Joseph W.
Akzo Nobel N.V.
Blackstone William M.
Gormley Mary E.
Jones W. Gary
Rees Dianne
LandOfFree
Detection of human retrovirus infection does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of human retrovirus infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of human retrovirus infection will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1987397