Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2003-08-22
2009-08-04
Switzer, Juliet C (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C435S091100, C536S023100, C536S024320, C536S024300
Reexamination Certificate
active
07569344
ABSTRACT:
Methods and reagents for detecting high-risk human papilloma virus (HPV) DNA types in cells on a Pap smear that indicates the patient is at higher risk for cancer are described. The method uses full-length DNA probes to HPV types 16, 18, 31, 33, 35, and 51 in a particular proportion to hybridize to and detect the viral DNA in situ. The method differentiates high-risk from low-risk HPV DNA in cells that indicates the patient's risk for cancer. The in situ hybridization is detected by brightfield microscopy.
REFERENCES:
patent: 4820530 (1989-04-01), Moran et al.
patent: 4849311 (1989-07-01), Itoh et al.
patent: 4849332 (1989-07-01), Lorincz
patent: 4849334 (1989-07-01), Lorincz
patent: 4908306 (1990-03-01), Lorincz
patent: 4983728 (1991-01-01), Herzog et al.
patent: 5057411 (1991-10-01), Lancaster et al.
patent: 5283171 (1994-02-01), Manos et al.
patent: 5411847 (1995-05-01), Leppard et al.
patent: 5484699 (1996-01-01), Bouma et al.
patent: 5501947 (1996-03-01), Emery et al.
patent: 5527898 (1996-06-01), Bauer et al.
patent: 5538871 (1996-07-01), Nuovo et al.
patent: 5554538 (1996-09-01), Cole et al.
patent: 5639871 (1997-06-01), Bauer et al.
patent: 5643715 (1997-07-01), Lancaster
patent: 5656423 (1997-08-01), Orth et al.
patent: 5679509 (1997-10-01), Wheeler et al.
patent: 5712092 (1998-01-01), Orth et al.
patent: 5783412 (1998-07-01), Morris et al.
patent: 5952487 (1999-09-01), Philipp et al.
patent: 5981173 (1999-11-01), Orth et al.
patent: 6855552 (2005-02-01), Towne et al.
patent: 6933117 (2005-08-01), Wolf et al.
patent: 0477972 (1996-09-01), None
Cox et al. (American Journal of Obstet. Gynecol. Mar. 1995, pp. 946-954).
Nuovo et al. (The Journal of Histotechnology, vol. 18, No. 2, Jun. 1995).
Nuovo et al. (Jun. 1998 Diagnostic Molecular Pathology 7(3): 158-163).
Medical FAQS on the Natural History of HPV, American Society for Colposcopy and Cervical Pathology. copyright 2001-2007. printed pp. 1-9. printed Jan. 8, 2007 from http://cme.asccp.org/faq/histHPV.cfm.
Togawa et al., Human papillomavurus-16 and -18 replication in esophagus squamous cancer cell line squamous cancer does not lines does not require heterologous E1 and E2 proteins., J. Med. Virol. 45:435-38 (1995).
Southern et al., “Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papilomaviruses.” Cancer Res., 57:4210-13 (1997).
Gravitt et al, “Genotyping of 27 human papilimavirus types by using L1 consensus PCR products by a singl-hybridization, reverse line blot detection method.” J. Clin. Microbiol. 36:3020-27 (1998).
Jacobs et al, A general primer GP5+/GP6+ mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papilomavirus genotypes in cervical scrapings. J. Clin. Microbiology, p. 901-905 (1995).
Cole, et al, “Nucleotide Sequence and Comparative Analysis of the Human Papillomavirus Type 18 Genome,” Journal of Molecular Biology , vol 193 ( No. 4), p. 599-608 (1987).
Ventana EZ Prep concentrate product sheet. 1113012003.
European Search Report, Jun. 2003.
Schiffman et al., “Accuracy and interlaboratory reliability of human papillomavirus DNA testing by hybrid culture.” J. Clin. Microbiol., p. 545-550 (1995).
Seedorf et al., “Human papilomavirus type 16 DNA sequence.” Virology, 145:181-185 (1985).
Kennedy et al., “Human papillomavirus type 16 (HPV16), complete genome”, NCBI Genbank database, Accession No. K02718 (1985).
Hirt et al., “Nucleotide sequence of human papillomavirus (HPV) type 41: an unusual HPV Type without a typical E2 binding site consensus sequence.” Virus Research, p. 179-189 (1991).
Jacobs et al, “Group-specific differentiation between high and low-risk human papillomavirus.” J. Clin. Microbiol., p. 901-905, (1997).
Herrington et al., “Interphase cytogenetics using biotin and dioxigenin labelled probes I: relative sensitivity of both molecules for detection of HPV16 in CaSki cells.” J. Clin. Pathol. 42:592-600 (1989).
Light Elizabeth S.
Nuovo Gerard J.
McDonnell Boehnen & Hulbert & Berghoff LLP
Switzer Juliet C
Ventana Medical Systems, Inc.
LandOfFree
Detection of human papilloma virus in papanicolaou (Pap) smears does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of human papilloma virus in papanicolaou (Pap) smears, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of human papilloma virus in papanicolaou (Pap) smears will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4100158