Detection of human cancer cells with antibodies to human cancer

Details Detection of human cancer cells with antibodies to human cancer Detection of human cancer cells with antibodies to human cancer

1980-09-29

1984-05-15

Nucker, Christine M.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Antinuclear

260112R, 422 61, 436547, 436813, 436808, G01N 3354, G01N 3358, C07G 700

Patent

active

044488904

ABSTRACT:
Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purified. Antibodies and antisera specific to these nucleolar antigens are harvested from non-human hosts and used for detection of human cancer cells. Disclosed are (1) methods for isolating the nucleolar antigens, obtaining them in substantially purified form, producing the specific antibodies, obtaining them in substantially purified form, and using the antisera and antibodies induced by the nucleolar antigens in diagnostic procedures for detecting human cancer cells, and (2) diagnostic kits comprising specific antibodies and antisera.

REFERENCES:
patent: 4296201 (1981-10-01), Ax et al.
Davis et al., Proc. Natl. Acad. Sci. U.S.A., vol. 76, Feb. 1979, pp. 892-896.

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