Detection of hepatitis B surface antigen

Details Detection of hepatitis B surface antigen Detection of hepatitis B surface antigen

1978-11-06

1980-05-13

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

424 12, G01N 3316

Patent

active

042026652

ABSTRACT:
The reversed passive hemagglutination test (RPHA) for the detection of hepatitis B surface antigen (HB.sub.s Ag) is improved by the recognition that the speed of movement towards the periphery of a centrifugal field by immunologically aggregated solid phase support particles, increases proportionally with the amount of antigen present. It is further recognized that this dynamic study can be performed objectively and in an automated fashion by equipment such as the miniature centrifugal fast analyzer. The test performed in this manner and known as "reversed passive hemagglutination by minature centrifugal fast analysis" (RPHA/MCFA) is highly specific and eliminates the need for subsequent confirmational studies. Preliminary studies confirm a sensitivity comparable to other third generation tests.

REFERENCES:
patent: 3829223 (1974-08-01), Hamel
patent: 3992517 (1976-11-01), Lowke
patent: 4080264 (1978-03-01), Cohen
patent: 4113712 (1978-09-01), Fundroshi
patent: 4130634 (1978-12-01), Molinaro
patent: 4133873 (1979-01-01), Noller
patent: 4136161 (1979-01-01), Falkowski

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