Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-08-07
2011-11-01
Chunduru, Prabha (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C514S04400A
Reexamination Certificate
active
08048629
ABSTRACT:
This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to those methods of detecting and monitoring tumor-associated DNA found in the plasma or serum fraction of blood by using DNA extraction and amplification with or without enrichment for DNA. The invention allows the selection and monitoring of patients for various cancer therapies including receptor tyrosine kinase inhibitor therapies.
REFERENCES:
patent: 4762706 (1988-08-01), McCormick et al.
patent: 4965188 (1990-10-01), Mullis
patent: 5024934 (1991-06-01), Lee
patent: 5028527 (1991-07-01), Carney
patent: 5088492 (1992-02-01), Takayama et al.
patent: 5174986 (1992-12-01), Berns
patent: 5182377 (1993-01-01), Manos
patent: 5283171 (1994-02-01), Manos
patent: 5288477 (1994-02-01), Bacus
patent: 5447839 (1995-09-01), Manos et al.
patent: 5496699 (1996-03-01), Sorenson
patent: 5512439 (1996-04-01), Hornes
patent: 5512441 (1996-04-01), Ronai
patent: 5514554 (1996-05-01), Bacus
patent: 5527676 (1996-06-01), Vogelstein
patent: 5527898 (1996-06-01), Bauer
patent: 5545527 (1996-08-01), Stevens et al.
patent: 5639871 (1997-06-01), Bauer
patent: 5648212 (1997-07-01), Albertsen et al.
patent: 5660834 (1997-08-01), Kjeldsen et al.
patent: 5705627 (1998-01-01), Manos
patent: 5716793 (1998-02-01), MacDonald et al.
patent: 5789190 (1998-08-01), Crabb et al.
patent: 5814448 (1998-09-01), Silverstein
patent: 5824311 (1998-10-01), Greene et al.
patent: 5888724 (1999-03-01), Silverstein et al.
patent: 5952170 (1999-09-01), Stroun et al.
patent: RE36713 (2000-05-01), Vogelstein
patent: 6071693 (2000-06-01), Cha et al.
patent: 6090566 (2000-07-01), Vogelstein
patent: 6156504 (2000-12-01), Gocke et al.
patent: 6329179 (2001-12-01), Kopreski
patent: 6383733 (2002-05-01), Beug et al.
patent: 6521409 (2003-02-01), Gocke et al.
patent: 6630301 (2003-10-01), Gocke et al.
patent: 6759217 (2004-07-01), Kopreski
patent: 6916634 (2005-07-01), Kopreski
patent: 6939671 (2005-09-01), Kopreski
patent: 6939675 (2005-09-01), Gocke et al.
patent: 7211600 (2007-05-01), Lipson et al.
patent: 7282335 (2007-10-01), Gocke et al.
patent: 0774518 (1997-05-01), None
patent: WO 8900206 (1989-11-01), None
patent: WO 91/02088 (1991-02-01), None
patent: WO 93/22456 (1993-11-01), None
patent: WO 9322456 (1993-11-01), None
patent: WO 95/13368 (1995-05-01), None
patent: WO 9516792 (1995-06-01), None
patent: WO 9615139 (1996-05-01), None
patent: WO 9734015 (1997-09-01), None
patent: WO 97/35589 (1997-10-01), None
patent: WO 98/58081 (1998-12-01), None
Albretsen et al. (1990), “Applications of magnetic beads with covalently attached oligonucleotides in hybridization: isolation and detection of specific measles virus mRNA from a crude cell lysate,” Anal. Biochem. 189(1): 40-50.
Anker et al. (1997), “K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer,” Gastroenterology 112(4): 1114-1120.
Capone et al. (2000), “Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma,” Clin Cancer Res. 6(11): 4171-4175.
Chelly et al. (1989), “Illegitimate transcription: Transcription of any gene in any cell type,” PNAS 86: 2617-2621.
Dix et al. (1995), “Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers,” Diagn. Molec. Pathol. 4: 261-265.
Dressler and Bartow (1989), “DNA flow cytometry in solid tumors: practical aspects and clinical applications,” Semin. Diagn. Pathol. 6(1): 55-82.
Duenas et al. (2000), “DNA of human papillomavirus detected by PCR in plasma of cervical cancer patients: a potential marker of residual disease,” CNAPS Symposium 47(2): 364.
Hornes et al. (1990), “Magnetic DNA hybridization properties of oligonucleotide probes attached to superparamagneetic beads and their use in the isolation of poly-A-mRNA from eukaryotic cells,” Genetic Analysis 7(6): 145-150.
Lankiewicz et al. (1997), “Enhanced RACE method using specific enrichment by biotinylated oligonucleotides bound to streptavidin coated magnetic particles,” Nucleic Acids Res. 25(10): 2037-2038.
Lejeune et al. (1993), “Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer,” Cancer Research 53: 3597-3602.
Moran et al. (1994), “Utilization of sigmoidoscopy,” Can. Med. Assoc. J. 150(10): 1544.
Ristamaki et al. (1994), “Serum CD44 in malignant lymphoma: an association with treatment response,” Blood 84(1): 238-243.
Runnebaum et al. (Feb. 6-9, 1996), “Tumor suppressor genes p53 and p21-WAF1/Cip1 in breast and ovarian cancer,” Abstract from Anti-Cancer Treatment, Sixth International Congress, p. 93.
Sidransky (1994), “Molecular screening—how long can we afford to wait?” J. Natl. Cancer Inst. 86(13): 955-956.
Silverman et al. (1989), “Abnormal methylation of the calcitonin gene in human colonic neoplasms,” Cancer Research 49: 3468-3473.
Urdea et al. (1994), “Branched DNA signal amplification,” Bio/Technology 12: 926-928.
Zehnder et al. (1997), “Cross-linking hybridization assay for direct detection of Factor V Leiden mutation,” Clin. Chem. 43(9): 1703-1708.
Aggarwal, et al., (Mar. 1975) “Cell-Surface-Associated Nucleic Acid in Tumorigenic Cells Made Visible with Platinum-Pyrimidine Complexes by Electron Microscopy.”Proc. Nat. Acad. Sci., vol. 72, No. 3, pp. 928-932.
Aoki et al., (Sep. 1995) “Liposome-mediated in vivo Gene Transfer of Antisense K-ras Construct Inhibits Pancreatic Tumor Dissemination in the Murine Peritoneal Cavity.”Cancer Research, 55:3810-3816.
Ausuker et al., Editions Short Protocols in Molecular Biology John Wiley & Sons, New. York pp. 72-80, 1989.
Barz et al., (1985) “Characterization of cellular and extracellular plasma membrane vesicles from a non-metastasizing lymphoma (Eb) and its metastasizing variant (EESb).”Biochimica et Biophysica Acta, 814:7-84.
Blackburn et al., (1991) “Electrochemiluminescence Detection of Immunoassays and DNA Probe Assays for Clinical Diagnostics.”Clin. Chem., vol. 37, No. 9, pp. 1534-1539.
Bobo et al., (Sep. 1990) “Diagnosis of Chylamydia trachomatis Cervical Infection by Detection of Amplified DNA with and Enzyme Immunoassay.”Journal of Clinical Microbiology, vol. 28, No. 9, 1968-973.
Boland, Richard, (Sep. 1996) “Setting microsatellites free”Nature Medicine, vol. 2, No. 9, pp. 972-974.
Boom et al., (Mar. 1990) “Rapid and Simple Method for Purification of Nucleic Acids.”Journal of Clinical Microbiology, vol. 28, No. 3, pp. 495-303.
Boom et al., (Sep. 1991) “Rapid Purification of Hepatitis B Virus DNA from Serum.”Journal of Clinical Microbiology, vol. 29, No. 9, pp. 1804-1811.
Bos et al., (May 1987) “Prevalence of ras gene mutations in human colorectal cancers.”Nature, vol. 327, pp. 293-297.
Carr et al., (Nov. 1985) “Circulating Membrane Vesicles in Leukemic Blood.”Cancer Research, 45: 5944-5951.
Chaubert et al., (1994) “K-ras Mutations and p53 Alterations in Neoplastic and Nonneoplastic Lesions Associated with Longstanding Ulcerative Colitis.”Amer. Jrnl. of Path., vol. 144, No. 4, pp. 767-774.
Chen et al., (1991) “A Method to Detect ras Point Mutations in Small Subpopulations of Cells.”Analytical Biochemistry, 195: 51-56.
Chen et al., (Sep. 1996) “Microsatellite alterations in plasma DNA of small cell lung cancer patients.”Nature Medicine, vol. 2, No. 9, pp. 1033-1035.
Chen et al., “Detecting Tumor-related Alteractions in Plasma or Serum DNA of patients Diagnosed with Breast Cancer,” Clinical Cancer Research, Sep. 1999 vol. 5
Gocke Christopher D.
Kopreski Michael S.
Chunduru Prabha
McDonnell Boehnen Hulbert & Berhoff.
The Penn State Research Foundation
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