Detection of erythropoietin and erythropoietin receptor

Details Detection of erythropoietin and erythropoietin receptor Detection of erythropoietin and erythropoietin receptor

2007-12-25

2007-12-25

Rio-Gabel, Gailene (Department: 1641)

Chemistry: analytical and immunological testing

Involving antibody fragments

C436S519000, C436S524000, C436S528000, C436S165000, C436S172000, C436S809000, C436S007000, C436S007000, C436S007000, C436S169000, C435S003000, C435S007100, C435S007720, C435S007920, C435S336000, C435S343000, C435S287200

Reexamination Certificate

active

10240988

ABSTRACT:
The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents are useful for differential diagnosis in Epo and EpoR related clinical problems. Methods and kits for simultaneous measurement of erythropoietin and erythropoietin receptor in a biological sample are described.

REFERENCES:
patent: 5712370 (1998-01-01), Fibi et al.
patent: 5843726 (1998-12-01), Lee
patent: 5885574 (1999-03-01), Elliott
patent: 6153190 (2000-11-01), Young et al.
Noe et al., A sensitive sandwich ELISA for measuring erythropoietin in human serum, British Journal of Haematology, (Mar. 1992) vol. 80, No. 3, pp. 285-292.
Kasai et al., Sensitive sandwich enzyme immunoassay for human Epo. Clin. Chem. Enzym. Comms. (1990), vol. 2: 137-143.
Wognum et al., An enzyme-linked immunosorbent assay for erythropoietin using monoclonal antibodies, tetrameric immune complexes, and substrate amplification. Blood, (Aug. 1, 1989) vol. 74, No. 2, pp. 622-628.
D'Andrea et al., Anti-erythropoietin receptor monoclonal antibodies Inhibit erythropoietin binding and neutralize bioactivity, Blood 82 (1): 46-52 (Jul. 1, 1993).
Spirak, et al. Solid-Phase Binding Assay for Erythropoietin Antibodies. Proceedings of the Society for Experimental Biology and Medicine, 169, 406-412 (1982).
Wognum, et al. An Enzyme-Linked Immunosorbent Assay for Erythropoietin Using Monoclonal antibodies, Tetrameric Immune, and Substrate Amplification. Blood, 72, 622-628 (1989).
Elliot et al. Activation of the Erythropoietin (EPO) Preceptor by Bivalent Anti-EPO Receptor Antibodies. Journal of Biological Chemistry, 271, 24691-24697.

Affiliated with

Also associated with

Rating

Detection of erythropoietin and erythropoietin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of erythropoietin and erythropoietin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of erythropoietin and erythropoietin receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3853176