Detection of dysplastic or neoplastic cells using anti-MCM2...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

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C424S138100

Reexamination Certificate

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07459157

ABSTRACT:
Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of the cervix (both biopsy and smear samples), breast, colon, lung, bladder, skin, larynx, esophagus, bronchus, lymph nodes and urinary tract (both biopsy and cytology smear samples), in determination of cancerous and pre-cancerous cellular growth abnormality, and cells spun from urine, blood and serum, in determination of hematological malignancies and evidence of metastatic sarcoma and carcinoma.

REFERENCES:
patent: 5851821 (1998-12-01), Williams et al.
patent: 6007996 (1999-12-01), McNamara et al.
patent: 6303323 (2001-10-01), Laskey
patent: 7056690 (2006-06-01), Laskey
patent: 0 157 613 (1985-10-01), None
patent: 0 812 594 (1997-12-01), None
patent: WO 9716731 (1997-05-01), None
patent: 97/41153 (1997-11-01), None
patent: 98/09170 (1998-03-01), None
Todorov et al. (Laboratory Investigation, vol. 78, No. 1, 1998, p. 73-78).
Chatrath et al, British Journal of Cancer (2003), vol. 89, pp. 1048-1054.
Scott et al, Journal of Pathology, 2003, vol. 201, pp. 187-197.
Davies et al, Colorectal Disease, 2004, vol. 6, pp. 103-110.
Dudderidge et al, Clin Cancer Res 2005, vol. 11, No. 7, pp. 2510-2517.
Wharton et al, Neuropathology and Applied Neurobiology, 2001, vol. 27, pp. 305-313.
Hiraiwa, et al., “J. Cutan Pathol” Jul. 1998; 25(6):285-90.
Immunolocalization of Hcdc47 Protein in Normal and Neoplastic Human Tissues and its Relation to Growth, Int J. Cancer (Pred. Oncol.): 74, 180-184 1997.
Williams et al., “A human protein related to yeast Cdc6p”, Abstract, Proc. Natl. Acad. Sci. USA (1997), 94 (1), 142-147.
Hiraiwa et al., “Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth”, Abstract, Int. J. Cancer (1997) 74 (2), 180-184.
Williams et al., “Improved cervical smear assessment using antibodies against proteins that regulate DNA replication”, Abstract, Proc. Natl. Acad. Sci. USA (Dec. 8, 1998) 95 (25) 14932-7.
Hiraiwa et al., “Immunolocalization of hCDC47 Protein in Normal and Neoplastic Human Tissues and its Relation to Growth”, Int. J. Cancer 74, 180-184 (1997)—The Article.
Todorov et al “HsMCM2/BM28: A Novel Proliferation Marker for Human Tumors and Normal Tissues”, Laboratory Investigation, Jan. 1998, vol. 78, No. 1, pp. 73-78.
Gavin et al, Science 1995; vol. 270, pp. 1667-1671.
Todorov et al, 1994, J. Cell Science, 107, 253-265, GenBank Acc. No. X67334.
Werness et al, Laboratory Investigation, vol. 76, No. 1, p. 185A, Mar. 1997.
Murphy et al, Clinical Oncology, American Cancer Society, 2ndedition, 1995, pp. 553-554.

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