Detection of DNA damage

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S325000, C435S326000, C435S332000, C435S333000

Reexamination Certificate

active

07972781

ABSTRACT:
The health condition of a living organism is detected by electrochemically analyzing samples from selected areas of the body of said living organism for elevated free levels of nucleotide excision products resulting from DNA or RNA damage.

REFERENCES:
patent: 5104639 (1992-04-01), Matson
patent: 6096556 (2000-08-01), Heinecke
patent: 6268220 (2001-07-01), Heinecke
patent: 6410274 (2002-06-01), Bhikhabhai
patent: 6544734 (2003-04-01), Briscoe et al.
patent: 6548252 (2003-04-01), Matson
patent: WO 97/27327 (1997-07-01), None
patent: PCT/US98/22275 (1998-10-01), None
patent: WO 98/10294 (1998-12-01), None
Maeng et al., “Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromium,” Mutation Research, 2003, vol. 539, pp. 109-116.
“A Carbon Column-based Liquid Chromatography Electrochemical Approach to Routine 8-Hydroxy-2'-Deoxyguanosine Measurements in Urine and Other Biologic Matrices: A One-Year Evaluation of Methods” by Mikhail Bogdanov, et al Free Radical Biology & Medicine, vol. 27, Nos. 5/6, pp. 647-666, 1999.
“Simultaneous Analysis of the Majority of Low-Molecular-Weight, Redox-Active Compounds from Mitochondria”, by Bruce Kristal, et al, Analytical Biochemistry 263, pp. 18-25 (1998) Artticle No. AB982831.
“A Carbon Column-Based Liquid Chromatography Electrochemical Approach to Routine 8-hydroxy-2'-Deoxyguanosine Measurements in Urine and other Biologic Matrices: A One-Year Evaluation of Methods”, Bogdanov et al.,Free Radical Biology&Medicine, vol. 27, Nos. 5/6, 1999, pp. 647-666.
“Continuous Separations with Microfabricated Electrophoresis—Electrochemical Array Detection”, Gavin et al.,J. Am. Chem. Soc., 1996, 118, 8932-8936.
Stanley L. Hazen and Jay W. Heinecke “3-Chlorotyrosine, a Specific Marker of Myeloperoxidase-catalyzed Oxidation, is Markedly Elevated in Low Density Lipoprotein Isolated from Human Atherosclerotic Intima” Rapid Publication vol. 99, No. 9, May 1997, 2075-2081.
Hurst, The Journal of Clinical Investigation, vol. 109, pp. 127-1289, 2002. Van-der Vliet et al., American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 279, pp. L537-L546, Sep. 2000.
Hensley et al., Journal of High Resolution Chromatography,vol. 22, pp. 429-437, 1999.
“Oxidative DNA Base Damage in Cancerous Tissues of Patients Undergoing Brachytherapy” Foksinski et al., Cancer Letters 132, 1998, p. 169-173.
Helbock, H. J. et al.: “8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage.” Methods in Enzymology, 1999, vol. 300, 1999, pp. 156-166.
Souliotis, V. L. et al.: “Measurement of 0-6 methylguanine-type adducts in DNA and 0-6 alkylguanine-DNA-Alkyltransferase repair activity in normal and neoplastic human tissues.” Comparative Biochemistry and Physiology B, vol. 101, No. 1-2, 1992, pp. 269-275.
Bianchini, F. et al.: “Quantification of 7-methyldeoxyguanosine using Immunoaffinity purification and HPLC with electrochemical detection.” Carcinogenesis (Oxford), vol. 14, No. 8, 1993, pp. 1677-1682.
Whiteman, Matthew et al.: “Hypochlorous acid-induced DNA base modification: potentiation by nitrite: Biomarkers of DNA damage by reactive oxygen species.” Biochemical and Biophysical Research Communications, vol. 257, No. 2, Apr. 13, 1999, pp. 572-576.
Yu, Fei et al.: “Room temperature derivatization of 5-hydroxy-2'-deoxycytidine and 5?hydroxymethyl-2'-deoxyuridine for analysis by GC/MS.” Jan. 1999, Biomarkers, vol. 4, nr. 1, pp. 85-92.
Petruzzelli, Stefano et al.: “Plasma 3-nitrotyroslne in cigarette smokers.” American Journal of Respiratory and Critical Care Medicine, vol. 156, No. 6, Dec. 1997, pp. 1902-1907.
Zwingmann, Ivo H. et al.: “Analysis of oxidative DNA damage and HPRT mutant frequencies in cancer patients before and after radiotherapy.” Dec. 17, 1999, Mutation Research, vol. 431, nr. 2, pp. 361-369.
Toyokuni, S. et al.: “Quantitative immunohistochemical determination of 8?hydroxy?2'-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model.” 1997, Laboratory Investigation, United States and Canadian Academy of Pathology, Baltimore, US, pp. 365-374.
Lenton, Kevin J. et al.: “Glutathione and ascorbate are negatively correlated with oxidative DNA damage in human lymphocytes.” Apr. 1999, Carcinogenesis (Oxford). vol. 20, nr. 4, pp. 607-613.
Shuker, David E. G. et al.: “Urinary markers for measuring exposure to endogenous and exogenous alkylating agents and precursors.” 1993, Environmental Health Perspectives, vol. 99, nr. 0, pp. 33-37, Symposium on Biomarkers in Human Cancer, Part II: Exposure Monitoring and Molecular Dosimetry; Kailua-Kona, Hawaii, USA: Oct. 26-Nov. 1, 1991.
Jenner, Andrew et al.: “Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: Ethanethiol prevents artifactual generation of oxidized DNA bases.” Apr. 15, 1998, Biochemical Journal, vol. 331, nr. 2, pp. 365-369.
Yermilov, Vladimir et al.: “Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro.” 1995 Carcinogenesis (Oxford), vol. 16, nr. 9. pp. 2045-2050.
Ohshima, H. et al.: “Formation of 8-nitroguanine in DNA by peroxynitrite: A possible marker for DNA damage induced by reactive nitrogen species in inflamed tissues.” Proceedings of the American Association for Cancer Research Annual Meeting, vol. 37, No. 0, 1996, p. 143, & 87th Annual Meeting of the American Association for Cancer Research; Washington, D.C., USA; Apr. 20-24, 1996.
Chung, Fung-Lung: “The prevention of lung cancer Induced by a tobacco-specific carcinogen in rodents by green and black tea.” Apr. 1999, Proceedings of the Society for Experimental Biology and Medicine, vol. 220, nr. 4, pp. 224-248, 2nd International Scientific Symposium on Tea and Human Health; Washington, D.C., USA; Sep. 14-15, 1998.
Shen, Zhongzhou et al.: “Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical.” Biochemistry, vol. 39, No. 18, May 9, 2000, pp. 5474-5482.
Kaur, Harparkash et al.: “Measurement of oxidized and methylated DNA bases by HPLC with electrochemical detection.” Biochemical Journal, vol. 318, No. 1, 1996, pp. 21-23.
Gal, A. et al.: “Nitrotyrosine formation, apoptosis, and oxidative damage: Relationships to nitric oxide production in SJL mice bearing the ResX tumor.” Cancer Research, May 15, 1997, vol. 57, No. 10, pp. 1823-1828.
Foksinski et al., “Oxidative DNA base damage in cancerous tissues of patients undergoing brachytherapy,” Cancer Letters, 1998, vol. 169-173.
Hazen et al. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human antherosclerotic intima. Journal of clinical investigation, vol. 99, No. 9, pp. 2075-2081.
Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2'deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutation Research, vol. 387, pp. 147-163, Dec. 1997.
“Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage”, Shigenaga et al., Proceedings of the National Academy of Sciences,USA, Dec. 1989; vol. 86, pp. 9697-9701.
“Assays of Oxidative DNA Damage Biomarkers 8-Oxo-2'-deoxyguanosine and 8-Oxoguanine in Nuclear DNA and Biological Fluids by High-Performance Liquid Chromatography with Electrochemical Detection”, Shigenaga et al., Methods in Enzymology, 1994, vol. 234, pp. 16-33.

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